Document Detail

Effects of N-acetylcysteine on bacterial clearance.
MedLine Citation:
PMID:  8911862     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to investigate whether the oxygen radical scavenger N-acetylcysteine (N-AC) impairs bacterial clearance, thus predisposing the host to increased risk of disease. Blood clearance of Escherichia coli and organ colonization were investigated in anaesthetized rabbits after pretreatment with N-AC (250 mg kg-1 body weight, n = 16) and in sham-operated animals (n = 12). To enable quantification of the clearance process, defined numbers of exogenous E. coli [1.3 x 108 colony-forming units (CFUs)] were injected intravenously. Parameters monitored were kinetics of bacterial elimination from the blood, and polymorphonuclear leucocyte (PMN) oxidative burst activity. Samples of liver, kidney, spleen and lung were collected for bacterial counts. Compared with controls, pretreatment with N-AC resulted in delayed bacterial elimination from blood and higher organ colonization with increased numbers of E. coli in liver, lung and kidney (P < 0.05). N-AC treatment was associated with a suppressed PMN oxidative burst activity. Impaired bacterial clearance and enhanced organ colonization in N-AC-treated animals correlated with reduced oxidative burst activity, suggesting impaired granulocyte-dependent bacterial killing due to N-AC application.
T Koch; S Heller; S Heissler; I Breil; H G Schiefer; K van Ackern; H Neuhof
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of clinical investigation     Volume:  26     ISSN:  0014-2972     ISO Abbreviation:  Eur. J. Clin. Invest.     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1997-02-13     Completed Date:  1997-02-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0245331     Medline TA:  Eur J Clin Invest     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  884-92     Citation Subset:  IM    
Institut für Anaesthesiologie und Operative Intensivmedizin, Klinikum Mannheim, Fakultät für Klinische Medizin Mannheim, Universität Heidelberg, Germany.
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MeSH Terms
Acetylcysteine / toxicity*
Bacterial Infections / immunology*
Blood Bactericidal Activity / drug effects*
Hemodynamics / drug effects
Leukocyte Count
Neutrophils / drug effects*,  physiology
Respiratory Burst
Reg. No./Substance:

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