Document Detail

Effects of N-butyl-2-cyanoacrylate on high-level jejunojejunostomy.
MedLine Citation:
PMID:  19907184     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Morbidity and mortality due to anastomotic complications in gastrointestinal surgery remain important problems. The tissue adhesive N-butyl-2-cyanoacrylate (NB2CA) is used in many fields of surgery. This study was designed to assess the effects of NB2CA on high-level jejunojejunostomy. MATERIALS AND METHODS: Forty male albino Wistar rats were divided into 4 groups of 10 each. The groups were treated as follows: group 1 underwent only a jejunojejunostomy, group 2 underwent jejunojejunostomy followed by NB2CA application around the anastomosis, group 3 underwent jejunojejunostomy after a 60-min ischemia and a 60-min reperfusion, and group 4 underwent jejunojejunostomy after a 60-min ischemia and a 60-min reperfusion followed by NB2CA application around the anastomosis. At postoperative day 7, the subjects in all groups were sacrificed. Intra-abdominal adhesions, anastomotic complications and anastomotic burst pressures (ABP) were recorded. RESULTS: The analysis of all the groups for adhesion scores and ABP showed statistical significance (p < 0.001). CONCLUSIONS: The use of NB2CA had positive effects in terms of increasing ABP both with and without the initial ischemia- reperfusion insult. However, it had the adverse effect of significantly increasing the number of intra-abdominal adhesions.
C O Ensari; V Genc; A Cakmak; B Erkek; K Karayalcin
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Publication Detail:
Type:  Journal Article     Date:  2009-11-12
Journal Detail:
Title:  European surgical research. Europ?ische chirurgische Forschung. Recherches chirurgicales europ?ennes     Volume:  44     ISSN:  1421-9921     ISO Abbreviation:  Eur Surg Res     Publication Date:  2010  
Date Detail:
Created Date:  2010-01-13     Completed Date:  2010-04-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0174752     Medline TA:  Eur Surg Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  13-6     Citation Subset:  IM    
Copyright Information:
Copyright 2009 S. Karger AG, Basel.
Department of Surgery, Ankara University Medical School, Ankara, Turkey.
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MeSH Terms
Anastomosis, Surgical
Enbucrilate / therapeutic use*
Jejunum / surgery*
Postoperative Complications / prevention & control*
Rats, Wistar
Tissue Adhesions / prevention & control*
Reg. No./Substance:

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