Document Detail

Effects of mother's dietary exposure to acesulfame-K in Pregnancy or lactation on the adult offspring's sweet preference.
MedLine Citation:
PMID:  21653241     Owner:  NLM     Status:  MEDLINE    
This study investigates whether mother's exposure to the artificial sweetener acesulfame-K (AK) during pregnancy or lactation affected her adult offspring's sweet preference. It was found that mother's dietary exposure to AK in pregnancy or lactation decreased the preference thresholds for AK and sucrose solutions in the adult offspring, whereas the preference pattern and the most preferred concentration for AK or sucrose solution were unchanged. Furthermore, the preference scores in the exposure groups were increased significantly when compared with the control group at a range of concentrations for AK or sucrose solution. The existence of AK and its dynamic changes within 24 h in amniotic fluid during pregnancy or in mother's milk during lactation after a single oral infusion of AK solution were revealed by the methods of reversed-phase high-performance liquid chromatography and mass spectrometry. Our data suggest that AK can be ingested by the prenatal or postnatal mice through their mother's amniotic fluid or breast milk, producing a long-dated function on the adult's sweet preference.
Gen-Hua Zhang; Meng-Ling Chen; Si-Si Liu; Yue-Hua Zhan; Ying Quan; Yu-Mei Qin; Shao-Ping Deng
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-06-07
Journal Detail:
Title:  Chemical senses     Volume:  36     ISSN:  1464-3553     ISO Abbreviation:  Chem. Senses     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-10-18     Completed Date:  2012-02-14     Revised Date:  2013-04-04    
Medline Journal Info:
Nlm Unique ID:  8217190     Medline TA:  Chem Senses     Country:  England    
Other Details:
Languages:  eng     Pagination:  763-70     Citation Subset:  IM    
Sensory Science Laboratory, School of Bioscience and Food Engineering, Changshu Institute of Technology, Changshu, Jiangsu Province, People's Republic of China.
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MeSH Terms
Chromatography, High Pressure Liquid
Food Preferences / drug effects*
Maternal Exposure
Maternal-Fetal Exchange
Mice, Inbred ICR
Prenatal Exposure Delayed Effects*
Taste / drug effects,  physiology*
Thiazines / pharmacology*
Reg. No./Substance:
0/Thiazines; 57-50-1/Sucrose; MA3UYZ6K1H/acetosulfame

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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