| Effects of Mother's Dietary Exposure to Acesulfame-K in Pregnancy or Lactation on the Adult Offspring's Sweet Preference. | |
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MedLine Citation:
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PMID: 21653241 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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This study investigates whether mother's exposure to the artificial sweetener acesulfame-K (AK) during pregnancy or lactation affected her adult offspring's sweet preference. It was found that mother's dietary exposure to AK in pregnancy or lactation decreased the preference thresholds for AK and sucrose solutions in the adult offspring, whereas the preference pattern and the most preferred concentration for AK or sucrose solution were unchanged. Furthermore, the preference scores in the exposure groups were increased significantly when compared with the control group at a range of concentrations for AK or sucrose solution. The existence of AK and its dynamic changes within 24 h in amniotic fluid during pregnancy or in mother's milk during lactation after a single oral infusion of AK solution were revealed by the methods of reversed-phase high-performance liquid chromatography and mass spectrometry. Our data suggest that AK can be ingested by the prenatal or postnatal mice through their mother's amniotic fluid or breast milk, producing a long-dated function on the adult's sweet preference. |
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Authors:
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Gen-Hua Zhang; Meng-Ling Chen; Si-Si Liu; Yue-Hua Zhan; Ying Quan; Yu-Mei Qin; Shao-Ping Deng |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-7 |
Journal Detail:
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Title: Chemical senses Volume: - ISSN: 1464-3553 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-6-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8217190 Medline TA: Chem Senses Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Sensory Science Laboratory, School of Bioscience and Food Engineering, Changshu Institute of Technology, Changshu 215500, People's Republic of China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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