| Effects of Mono- and Dual Blockade of the Renin-Angiotensin System on Markers of Cardiovascular Status in Hypertensive Patients with Mild and Moderate Renal Failure. | |
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MedLine Citation:
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PMID: 21372591 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background/Aims: Dual renin-angiotensin system (RAS) blockade has no more efficiency to decrease cardiovascular mortality than mono-blockade. Our goal was to explore differences between other cardiovascular markers in patients with RAS blockade. Methods: We analyzed two groups of patients treated with a long-term ACE inhibitor (MONO-group, n = 20) and an ACE inhibitor and angiotensin II receptor blocker (DUAL-group, n = 15). Ambulatory blood pressure monitoring, echocardiography, arterial stiffness and levels of catecholamine, endogenous ouabain (EO), pro-brain natriuretic peptide and more types of urinary albumin measurements were performed. Results: In the DUAL-group, we found significantly better cardiac parameters, but the levels of EO and urinary albumins were similar in both groups. The level of EO correlates with nighttime mean arterial blood pressure (R = 0.556, p = 0.032) and arterial β-stiffness (R = 0.512, p = 0.042). Urinary immuno-unreactive albumin showed a relationship with diastolic dysfunction of the heart (R = -0.508, p = 0.045) diurnal index of diastolic blood pressure (R = -0.569, p = 0.021) in the MONO-group. Conclusion: Cardiac parameters were more prosperous in the DUAL-group, but the levels of EO did not differ between groups. The level of EO correlated with blood pressure and arterial stiffness markers in the MONO-group only. The urinary immuno-unreactive albumin may be a new marker of cardiovascular conditions. |
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Authors:
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Gábor Nagy; István A Szijártó; Balázs Gaszner; Eva Lányi; Lajos Markó; Akos Mérei; Gergő A Molnár; Kinga Németh; József Betlehem; István Wittmann |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-03 |
Journal Detail:
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Title: Kidney & blood pressure research Volume: 34 ISSN: 1423-0143 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9610505 Medline TA: Kidney Blood Press Res Country: - |
Other Details:
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Languages: ENG Pagination: 150-157 Citation Subset: - |
Copyright Information:
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Copyright © 2011 S. Karger AG, Basel. |
Affiliation:
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2nd Department of Medicine and Nephrological Center, Faculty of Medicine, University of Pécs, Pécs, Hungary. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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