Document Detail

Effects of MnDPDP, DPDP--, and MnCl2 on cardiac energy metabolism and manganese accumulation. An experimental study in the isolated perfused rat heart.
MedLine Citation:
PMID:  9101355     Owner:  NLM     Status:  MEDLINE    
RATIONALE AND OBJECTIVES: Recent studies indicate that manganese dipyridoxyl diphosphate (MnDPDP) may function as a slow release agent for manganese ions (Mn++) and that MnDPDP is approximately 10 times less potent than manganese chloride (MnCl2) in depressing cardiac function. The authors examined the possibility that MnDPDP and MnCl2 may influence cardiac metabolism and enzyme release and lead to a tissue accumulation of Mn. METHODS: Manganese DPDP, DPDP--, or MnCl2 (1000 microM) was infused in isolated rat hearts, which were freeze-clamped at various time intervals during infusion (5 minutes) and recovery (14-minute washout). Enzyme (lactate dehydrogenase) release, tissue high energy phosphates, Mn contents, and physiologic indices were measured at various time intervals. RESULTS: No significant differences were noted for: lactate dehydrogenase in the treated groups; tissue creatine phosphate (CrP) and adenosine triphosphate in MnDPDP, DPDP--, and control groups; and tissue Mn in DPDP-- and control groups. Manganese-chloride and MnDPDP-treated hearts accumulated and retained Mn in an 8:1 ratio. Manganese chloride depressed cardiac function more effectively than MnDPDP. CONCLUSIONS: The study has shown that: heart tissue uptake and retention of Mn++ is rapid and effective; MnCl2 is approximately eight times more potent than MnDPDP in promoting these effects; and a rise in tissue Mn content to eight to nine times (MnDPDP) or 60 to 70 times (MnCl2) the normal level does not lead to acute side effects on cardiac energy metabolism, function, and enzyme release. The study indicates that MnDPDP may act like a slow release compound for Mn++ ions.
H Brurok; J Schjøtt; K Berg; J O Karlsson; P Jynge
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Investigative radiology     Volume:  32     ISSN:  0020-9996     ISO Abbreviation:  Invest Radiol     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-06-23     Completed Date:  1997-06-23     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0045377     Medline TA:  Invest Radiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  205-11     Citation Subset:  IM    
Department of Physiology and Biomedical Engineering, Faculty of Medicine, Norwegian University of Science and Technology, Oslo, Norway.
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MeSH Terms
Chlorides / pharmacokinetics,  pharmacology*
Contrast Media / pharmacokinetics,  pharmacology*
Edetic Acid / analogs & derivatives*,  pharmacokinetics,  pharmacology
Energy Metabolism / drug effects*
Heart / drug effects*
Manganese / pharmacokinetics,  pharmacology*
Manganese Compounds / pharmacokinetics,  pharmacology*
Myocardium / enzymology,  metabolism*
Pyridoxal Phosphate / analogs & derivatives*,  pharmacokinetics,  pharmacology
Rats, Wistar
Time Factors
Reg. No./Substance:
0/Chlorides; 0/Contrast Media; 0/Manganese Compounds; 119797-12-5/N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid; 54-47-7/Pyridoxal Phosphate; 60-00-4/Edetic Acid; 7439-96-5/Manganese; 7773-01-5/manganese chloride

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