| Effects of midodrine hydrochloride on blood pressure and cerebral blood flow during orthostasis in persons with chronic tetraplegia. | |
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MedLine Citation:
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PMID: 20801263 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the mean arterial pressure (MAP) and middle cerebral artery mean blood flow velocity (MFV) responses to 5 and 10mg midodrine during head-up tilt (HUT) in persons with tetraplegia. DESIGN: Prospective dose-response trial. SETTING: James J. Peters Veterans Administration Medical Center. PARTICIPANTS: Persons (N=10) with chronic tetraplegia (duration of injury=23+/-11 y). INTERVENTION: A dose titration study was performed over 3 testing days: control (no drug), 5mg midodrine (5mg), or 10mg midodrine (10mg) during 30 minutes of baseline (predrug/no drug), 30 minutes of supine rest postdrug/no drug, 15 minutes of progressive HUT (5 minutes at 15 degrees , 25 degrees , 35 degrees ), and 45 minutes of 45 degrees HUT. MAIN OUTCOME MEASURES: MAP and MFV response to midodrine supine and during HUT. RESULTS: Ten milligrams of midodrine significantly increased MAP while supine and during the HUT maneuver. Of note, the mean increase in MAP during HUT with 10mg was a result of a robust effect in 2 persons, with minimal change in the remaining 8 study subjects. The reduction in cerebral MFV during HUT was attenuated with 10mg. CONCLUSIONS: These findings suggest that midodrine 10mg may be efficacious for treatment of hypotension and orthostatic hypotension in select persons with tetraplegia. Although midodrine is routinely prescribed to treat orthostatic hypotension, the results of our work suggests limited efficacy of this agent, but additional studies in a larger sample of subjects with spinal cord injury should be performed. |
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Authors:
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Jill M Wecht; Dwindally Rosado-Rivera; John P Handrakis; Miroslav Radulovic; William A Bauman |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Archives of physical medicine and rehabilitation Volume: 91 ISSN: 1532-821X ISO Abbreviation: Arch Phys Med Rehabil Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-30 Completed Date: 2010-09-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985158R Medline TA: Arch Phys Med Rehabil Country: United States |
Other Details:
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Languages: eng Pagination: 1429-35 Citation Subset: AIM; IM |
Affiliation:
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James J. Peters Veterans Administration Medical Center, Bronx, NY, USA. JM.WECHT@VA.GOV |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cerebrovascular Circulation / drug effects Dose-Response Relationship, Drug Female Humans Hypotension / drug therapy*, etiology Hypotension, Orthostatic / drug therapy, etiology Male Middle Aged Midodrine / pharmacology, therapeutic use* Quadriplegia / complications, rehabilitation* Spinal Cord Injuries / complications, rehabilitation* Tilt-Table Test Vasoconstrictor Agents / pharmacology, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Vasoconstrictor Agents; 42794-76-3/Midodrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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