Document Detail

Effects of Microdesmis keayana roots on sexual behavior of male rats.
MedLine Citation:
PMID:  18061417     Owner:  NLM     Status:  MEDLINE    
In the present study, the aphrodisiac properties of Microdesmis keayana J. Léonard root extract and major isolated alkaloids were evaluated by observing the sexual behavior of male rats. Aqueous extract (150mg/kg body weight) and pure alkaloids (3mg/kg body weight) were administered orally by gavage to male rats. Latent times of observation, intromission and ejaculation, mounting behavior, number of intromissions and mating performances were evaluated and compared to those obtained with untreated rats in the presence of receptive and non-receptive females. The results have shown that aqueous extract and alkaloids of M. keayana stimulate sexual parameters in rats' sexual behavior. A short-term toxicity study undertaken to establish the therapeutic index of aqueous extract, showed that a high dose of the extract (2g/kg body weight) caused no mortality or changes in rats' behavior.
A Zamblé; S Sahpaz; C Brunet; F Bailleul
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Publication Detail:
Type:  Journal Article     Date:  2007-12-03
Journal Detail:
Title:  Phytomedicine : international journal of phytotherapy and phytopharmacology     Volume:  15     ISSN:  1618-095X     ISO Abbreviation:  Phytomedicine     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-08     Completed Date:  2008-11-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9438794     Medline TA:  Phytomedicine     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  625-9     Citation Subset:  IM    
Laboratoire de Pharmacognosie (E.A. 1043), Faculté de Pharmacie, Université de Lille 2, B.P. 83, 59006 Lille Cedex, France.
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MeSH Terms
Angiosperms / chemistry*
Aphrodisiacs / chemistry,  pharmacology*
Coumaric Acids / chemistry,  pharmacology
Molecular Structure
Plant Extracts
Rats, Wistar
Sexual Behavior, Animal / drug effects*
Spermidine / analogs & derivatives,  chemistry,  pharmacology
Spermine / analogs & derivatives,  chemistry,  pharmacology
Reg. No./Substance:
0/Aphrodisiacs; 0/CML-1 plant extract; 0/Coumaric Acids; 0/Plant Extracts; 0/kearanine; 0/keayanidine B; 124-20-9/Spermidine; 71-44-3/Spermine

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