Document Detail


Effects of marine-derived omega-3 fatty acids on systemic hemodynamics at rest and during stress: a dose-response study.
MedLine Citation:
PMID:  22865498     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Omega-3 fatty acids reduced heart rate (HR) and blood pressure (BP) in some studies, but dose-response studies are rare, and little is known about underlying mechanisms.
PURPOSE: We examined effects of 0.85 g/day eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA) (low dose) and 3.4 g/day EPA + DHA (high dose) on HR and systemic hemodynamics during rest, speech, and foot cold pressor tasks.
METHODS: This was a dose-response, placebo-controlled, double-blind, randomized, crossover trial (8-week treatment, 6-week washout) in 26 adults.
RESULTS: Throughout the testing sessions, HR was reduced in a dose-dependent manner. The high dose reduced BP and stroke volume and increased pre-ejection period. Reductions in BP were associated with increases in erythrocyte omega-3 fatty acids.
CONCLUSIONS: High-dose long-chain omega-3 fatty acids can reduce BP and HR, at rest and during stress. These findings suggest that at-risk populations may achieve benefits with increased omega-3 intake. The trial was registered on ClinicalTrials.gov (NCT00504309).
Authors:
Ann C Skulas-Ray; Penny M Kris-Etherton; William S Harris; Sheila G West
Related Documents :
9751648 - Rhyme or reason: rna-arginine interactions and the genetic code.
476668 - Metabolic activation of arylhydroxamic acids by n-o-acyltransferase of rat mammary gland.
19153138 - A self-cleaving dna enzyme modified with amines, guanidines and imidazoles operates ind...
8595368 - The digoxigenin (dig) system for non-radioactive labelling and detection of nucleic aci...
20850128 - Electrophoretic deposition of tio2 and composite tio2-mno2 films using benzoic acid and...
15139378 - Hysterothylacium winteri sp. n. (nematoda: anisakidae), a parasite of chilean rock cod,...
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of behavioral medicine : a publication of the Society of Behavioral Medicine     Volume:  44     ISSN:  1532-4796     ISO Abbreviation:  Ann Behav Med     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-26     Completed Date:  2013-05-02     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  8510246     Medline TA:  Ann Behav Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  301-8     Citation Subset:  IM    
Affiliation:
Departments of Nutritional Sciences (ACS, PMKE, SGW) and Biobehavioral Health (SGW), Pennsylvania State University, University Park, PA 16802, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Blood Pressure / drug effects*
Cross-Over Studies
Docosahexaenoic Acids / administration & dosage,  pharmacology*
Dose-Response Relationship, Drug
Double-Blind Method
Eicosapentaenoic Acid / administration & dosage,  pharmacology*
Female
Heart Rate / drug effects*
Hemodynamics / drug effects
Humans
Male
Middle Aged
Stroke Volume / drug effects*
Grant Support
ID/Acronym/Agency:
M01 RR 10732/RR/NCRR NIH HHS; M01 RR010732/RR/NCRR NIH HHS; UL1 TR000127/TR/NCATS NIH HHS
Chemical
Reg. No./Substance:
1553-41-9/Eicosapentaenoic Acid; 25167-62-8/Docosahexaenoic Acids
Comments/Corrections
Comment In:
Ann Behav Med. 2012 Dec;44(3):295-6   [PMID:  22918613 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Antimicrobial use in the ICU: Indications and accuracy-an observational trial.
Next Document:  Life 1 year after a quit attempt: real-time reports of quitters and continuing smokers.