| The effects of macronutrient intake on total and high-molecular weight adiponectin: results from the OMNI-Heart trial. | |
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MedLine Citation:
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PMID: 19876001 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Higher levels of the adipocyte-specific hormone adiponectin have been linked to increased high-density lipoprotein (HDL) and lower insulin resistance. This study was conducted to determine the influence of macronutrient intake on adiponectin levels. One hundred and sixty-four pre- and stage-1 hypertensive adults participated in the Optimal Macro-Nutrient Intake Heart (OMNI-Heart) trial, a crossover feeding study originally testing the effects of macronutrients on blood pressure. Participants underwent three 6-week feeding periods: one rich in carbohydrates (CARB), one rich in monounsaturated fat (MUFA), and one rich in protein (PROT), while maintaining body weight. Their median plasma high molecular weight (HMW) and total adiponectin levels were 2.3 and 8.2 microg/ml, respectively, resulting in an average of 27% HMW adiponectin. Both HMW and total adiponectin levels decreased after baseline while the percent HMW adiponectin remained unchanged. Between diets, the MUFA diet maintained a higher level of both HMW and total adiponectin levels than either the CARB (HMW: +6.8%, P = 0.02; total: +4.5%, P = 0.001) or PROT (HMW: +8.4%, P = 0.003; total: +5.6%, P < 0.001) diets. Changes in total adiponectin levels were positively correlated to changes in HDL cholesterol irrespective of diets (Spearman r = 0.22-0.40). No correlation was found between changes in lipids, blood pressure, or insulin resistance by the homeostasis model assessment (HOMAIR). Macronutrient intake has effects on HMW and total adiponectin levels independent of weight loss. A diet rich in MUFA was associated with higher levels of total and HMW adiponectin in comparison to a carbohydrate- or protein-rich diet. Effects seen in adiponectin paralleled those found with HDL cholesterol. |
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Authors:
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Edwina H Yeung; Lawrence J Appel; Edgar R Miller; W H Linda Kao |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't Date: 2009-10-29 |
Journal Detail:
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Title: Obesity (Silver Spring, Md.) Volume: 18 ISSN: 1930-7381 ISO Abbreviation: Obesity (Silver Spring) Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-28 Completed Date: 2011-02-10 Revised Date: 2011-09-29 |
Medline Journal Info:
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Nlm Unique ID: 101264860 Medline TA: Obesity (Silver Spring) Country: United States |
Other Details:
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Languages: eng Pagination: 1632-7 Citation Subset: IM |
Affiliation:
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Epidemiology Branch, Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, Maryland, USA. yeungedw@mail.nih.gov |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adiponectin
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blood* Adult Cholesterol, HDL / blood* Cross-Over Studies Diet* Energy Intake* Fatty Acids, Monounsaturated / pharmacology Female Humans Male Middle Aged Single-Blind Method Statistics, Nonparametric |
| Grant Support | |
ID/Acronym/Agency:
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D63214//PHS HHS; HL67098/HL/NHLBI NIH HHS; HL68712/HL/NHLBI NIH HHS; K23 HL068712-01/HL/NHLBI NIH HHS; R01 HL067098-01A1/HL/NHLBI NIH HHS; RR02635/RR/NCRR NIH HHS; T32 DK62707-03/DK/NIDDK NIH HHS; Z99 HD999999/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adiponectin; 0/Cholesterol, HDL; 0/Fatty Acids, Monounsaturated |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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