Document Detail

Effects of MR imaging on murine natural killer cell cytotoxicity.
MedLine Citation:
PMID:  3492122     Owner:  NLM     Status:  MEDLINE    
To determine the effect of MR imaging on the immune system, 21 male C57BL/6 X DBA/2 F1 mice were exposed to MR imaging at a field strength of 0.15 T for 2 hr. Another nine mice (controls) were sham exposed for the same amount of time. Mice were sacrificed and their spleens removed 24, 72, and 144 hr after the exposure (MR or sham). Spleen cell suspensions were passed over nylon wool columns and then used as effector cells in a short-term natural killer cell cytotoxicity assay with 51Cr-labeled YAC-1 cells as target cells. The results showed no evidence of decreased cytotoxicity due to exposure to MR. On the contrary, at all three times after exposure and for all target-to-effector cell ratios, mean cytotoxicity was greater for MR-exposed groups than for sham-exposed groups. The results show that MR exposure has no adverse effect on the immune system, as evidenced by natural killer cell activity.
N Prasad; E Lotzová; J I Thornby; J E Madewell; J J Ford; S C Bushong
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  AJR. American journal of roentgenology     Volume:  148     ISSN:  0361-803X     ISO Abbreviation:  AJR Am J Roentgenol     Publication Date:  1987 Feb 
Date Detail:
Created Date:  1987-02-19     Completed Date:  1987-02-19     Revised Date:  2008-02-15    
Medline Journal Info:
Nlm Unique ID:  7708173     Medline TA:  AJR Am J Roentgenol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  415-7     Citation Subset:  AIM; IM    
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MeSH Terms
Cytotoxicity, Immunologic
Killer Cells, Natural / immunology*
Magnetic Resonance Spectroscopy / adverse effects*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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