Document Detail


Effects of MDMA ("ecstasy") during adolescence on place conditioning and hippocampal neurogenesis.
MedLine Citation:
PMID:  19932093     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The use of 3,4,methylenedioxymethamphetamine (MDMA), the active agent in ecstasy, during adolescence is widespread yet the effects on adolescent behavior and brain development are unknown. The aim of the present study was 1) to evaluate effects of MDMA in adolescent rats using the conditioned place preference (CPP) paradigm to measure MDMA-induced reward and 2) assess effects of MDMA administration on cellular proliferation, survival and neurogenesis in the dentate gyrus of the hippocampus. During the adolescent period, MDMA CPP was measured in adolescents [postnatal day (PND) 28-39] by training rats to associate 1.25, 2.5, 5.0mg/kg MDMA or saline administration with environmental cues. After CPP ended, bromodeoxyuridine (BrdU) was injected and rats were euthanized either 24h (to evaluate cell proliferation) or 2 weeks (to assess neurogenesis) after the last MDMA injection. Adolescents expressed a CPP for 2.5mg/kg MDMA. Repeated exposure to 5.0mg/kg MDMA during adolescence increased cell proliferation, yet diminished neurogenesis, an effect that was replicated using flow cytometry. These findings suggest differential dose effects of adolescent MDMA exposure on reward related behaviors and hippocampal neurogenesis.
Authors:
Briony J Catlow; Kimberly A Badanich; Ashley E Sponaugle; Amanda R Rowe; Shijie Song; Igor Rafalovich; Vasyl Sava; Cheryl L Kirstein; Juan Sanchez-Ramos
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-11-20
Journal Detail:
Title:  European journal of pharmacology     Volume:  628     ISSN:  1879-0712     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-27     Completed Date:  2010-04-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  96-103     Citation Subset:  IM    
Affiliation:
Department of Psychology, University of South Florida, Tampa, FL 33620, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Behavior, Animal / drug effects
Cell Survival / drug effects
Conditioning (Psychology) / drug effects*
Hippocampus / cytology*,  drug effects*,  physiology
Male
Motor Activity / drug effects
N-Methyl-3,4-methylenedioxyamphetamine / pharmacology*
Neurogenesis / drug effects*
Rats
Rats, Sprague-Dawley
Sexual Maturation / physiology*
Chemical
Reg. No./Substance:
42542-10-9/N-Methyl-3,4-methylenedioxyamphetamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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