Document Detail

Effects of low-level laser irradiation on rat skeletal muscle injury after eccentric exercise.
MedLine Citation:
PMID:  19697999     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVE: The effect of photobiomodulation on delayed onset muscle soreness remains unknown. This study represents the first investigation of this treatment using an animal model. METHODS: Seventy-two Sprague-Dawley rats were randomly divided into five groups: sedentary control group, exercise control group and three exercise-plus-laser groups. Downhill running was used to induce muscle injury in the gastrocnemius muscle. He-Ne laser irradiations were administered to the injured muscles immediately and at 18 and 42 h after exercise in the three exercise-plus-laser groups at 12, 28, and 43 J/cm2, respectively. Histological examination and serum creatine kinase (CK), muscle superoxide dismutase (SOD) and malondialdehyde (MDA) analyses were done at 24 and 48 h after exercise. RESULTS: The exercise control group exhibited a marked inflammation in the gastrocnemius muscle and significant elevations in serum CK activity and muscle MDA level after downhill running. He-Ne laser irradiation at 43 J/cm2 inhibited muscle inflammation, significantly enhanced muscle SOD activity and significantly reduced serum CK activity and muscle MDA level at both 24 and 48 h after exercise, whereas the irradiation at 12 or 28 J/cm2 slightly inhibited muscle inflammation and significantly reduced serum CK activity at 48 h after exercise only (P<0.05). CONCLUSIONS: Low-level He-Ne laser therapy could exert therapeutic effects on eccentric exercise-induced rat muscle injury through enhancing muscle anti-oxidative capacity and reducing the inflammatory reaction. The photobiomodulation was dose-dependent, and the 43 J/cm2 dose was the most efficient among the doses used.
Xiao-Guang Liu; Yong-Jian Zhou; Timon Cheng-Yi Liu; Jian-Qin Yuan
Related Documents :
15068829 - Creatine: are the benefits worth the risk?
21425889 - Interactive processes link the multiple symptoms of fatigue in sport competition.
16503679 - Mechanomyographic and electromyographic responses during submaximal to maximal eccentri...
9763649 - Damage to human muscle from eccentric exercise after training with concentric exercise.
6629599 - Myofibrillar damage following intense eccentric exercise in man.
10994909 - Activity and immobilization after eccentric exercise: i. recovery of muscle function.
24409029 - The effects of cognitive activity combined with active extremity exercise on balance, w...
23934179 - Associations between depressive symptoms, self-efficacy, eating styles, exercise and bo...
23651129 - Is applying the same exercise-based inpatient program to normal and reduced left ventri...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Photomedicine and laser surgery     Volume:  27     ISSN:  1557-8550     ISO Abbreviation:  Photomed Laser Surg     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-28     Completed Date:  2010-03-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101222340     Medline TA:  Photomed Laser Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  863-9     Citation Subset:  IM    
Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Analysis of Variance
Creatine Kinase / blood
Dose-Response Relationship, Radiation
Inflammation / radiotherapy*
Laser Therapy, Low-Level / methods*
Malondialdehyde / metabolism
Muscle, Skeletal / injuries*,  metabolism
Physical Conditioning, Animal
Random Allocation
Rats, Sprague-Dawley
Superoxide Dismutase / metabolism
Reg. No./Substance:
542-78-9/Malondialdehyde; EC Dismutase; EC Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Decorin gene delivery inhibits cardiac fibrosis in spontaneously hypertensive rats by modulation of ...
Next Document:  Development and characterization of minoxidil-loaded liposomal system for delivery to pilosebaceous ...