Document Detail


Effects of low-level laser irradiation on rat skeletal muscle injury after eccentric exercise.
MedLine Citation:
PMID:  19697999     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND OBJECTIVE: The effect of photobiomodulation on delayed onset muscle soreness remains unknown. This study represents the first investigation of this treatment using an animal model. METHODS: Seventy-two Sprague-Dawley rats were randomly divided into five groups: sedentary control group, exercise control group and three exercise-plus-laser groups. Downhill running was used to induce muscle injury in the gastrocnemius muscle. He-Ne laser irradiations were administered to the injured muscles immediately and at 18 and 42 h after exercise in the three exercise-plus-laser groups at 12, 28, and 43 J/cm2, respectively. Histological examination and serum creatine kinase (CK), muscle superoxide dismutase (SOD) and malondialdehyde (MDA) analyses were done at 24 and 48 h after exercise. RESULTS: The exercise control group exhibited a marked inflammation in the gastrocnemius muscle and significant elevations in serum CK activity and muscle MDA level after downhill running. He-Ne laser irradiation at 43 J/cm2 inhibited muscle inflammation, significantly enhanced muscle SOD activity and significantly reduced serum CK activity and muscle MDA level at both 24 and 48 h after exercise, whereas the irradiation at 12 or 28 J/cm2 slightly inhibited muscle inflammation and significantly reduced serum CK activity at 48 h after exercise only (P<0.05). CONCLUSIONS: Low-level He-Ne laser therapy could exert therapeutic effects on eccentric exercise-induced rat muscle injury through enhancing muscle anti-oxidative capacity and reducing the inflammatory reaction. The photobiomodulation was dose-dependent, and the 43 J/cm2 dose was the most efficient among the doses used.
Authors:
Xiao-Guang Liu; Yong-Jian Zhou; Timon Cheng-Yi Liu; Jian-Qin Yuan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Photomedicine and laser surgery     Volume:  27     ISSN:  1557-8550     ISO Abbreviation:  Photomed Laser Surg     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-28     Completed Date:  2010-03-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101222340     Medline TA:  Photomed Laser Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  863-9     Citation Subset:  IM    
Affiliation:
Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, China.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Creatine Kinase / blood
Dose-Response Relationship, Radiation
Female
Inflammation / radiotherapy*
Laser Therapy, Low-Level / methods*
Malondialdehyde / metabolism
Muscle, Skeletal / injuries*,  metabolism
Physical Conditioning, Animal
Random Allocation
Rats
Rats, Sprague-Dawley
Superoxide Dismutase / metabolism
Chemical
Reg. No./Substance:
542-78-9/Malondialdehyde; EC 1.15.1.1/Superoxide Dismutase; EC 2.7.3.2/Creatine Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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