Document Detail

Effects of long-term intravenous administration of adrenomedullin (AM) plus hANP therapy in acute decompensated heart failure: a pilot study.
MedLine Citation:
PMID:  19346663     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: It was reported previously that 30 min administration of adrenomedullin (AM) improves hemodynamics in chronic stable heart failure patients. The present study was designed to examine whether long-term AM + human atrial natriuretic peptide (hANP) administration can be used as a therapeutic drug in patients with acute decompensated heart failure (ADHF) in clinical setting. METHODS AND RESULTS: Seven acute heart failure patients (74 +/- 5 years) with dyspnea and pulmonary congestion were studied. AM (0.02 microg x kg(-1) x min(-1)) + hANP (0.05 microg x kg(-1) x min(-1)) was infused for 12 h and then hANP (0.05 microg x kg(-1) x min(-1)) was infused for 12 h. Hemodynamic, renal, hormonal and oxidative stress responses were evaluated. AM + hANP significantly reduced mean arterial pressure, pulmonary arterial pressure and systemic and pulmonary vascular resistance without changing heart rate, and increased cardiac output for most time-points compared with those at baseline. In addition, AM + hANP reduced aldosterone, brain natriuretic peptide and free-radical metabolites compared with those at baseline (all P<0.05). AM + hANP increased urine volume and U(Na)V compared with baseline data. CONCLUSIONS: In this small, pilot trial, AM + hANP therapy had beneficial hemodynamic and hormonal effects in ADHF. Intravenous infusion of AM with hANP could be used as a therapeutic drug in ADHF. These data are preliminary and require confirmation in a larger clinical study.
Toshio Nishikimi; Tsuyoshi Karasawa; Chikako Inaba; Kimihiko Ishimura; Kazuyoshi Tadokoro; Shogo Koshikawa; Fumiki Yoshihara; Noritoshi Nagaya; Hideaki Sakio; Kenji Kangawa; Hiroaki Matsuoka
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-04-02
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  73     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-24     Completed Date:  2009-08-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  892-8     Citation Subset:  IM    
Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University, Mibu, Japan.
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MeSH Terms
Acute Disease
Adrenomedullin / administration & dosage*,  blood
Atrial Natriuretic Factor / administration & dosage*,  blood
Biological Markers / blood
Cardiovascular Agents / administration & dosage*,  blood
Drug Administration Schedule
Drug Therapy, Combination
Heart Failure / blood,  drug therapy*,  physiopathology
Hemodynamics / drug effects
Infusions, Intravenous
Kidney / drug effects,  physiopathology
Oxidative Stress / drug effects
Pilot Projects
Time Factors
Treatment Outcome
Urodynamics / drug effects
Reg. No./Substance:
0/Biological Markers; 0/Cardiovascular Agents; 148498-78-6/Adrenomedullin; 85637-73-6/Atrial Natriuretic Factor

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