| Effects of long-term intravenous administration of adrenomedullin (AM) plus hANP therapy in acute decompensated heart failure: a pilot study. | |
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MedLine Citation:
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PMID: 19346663 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: It was reported previously that 30 min administration of adrenomedullin (AM) improves hemodynamics in chronic stable heart failure patients. The present study was designed to examine whether long-term AM + human atrial natriuretic peptide (hANP) administration can be used as a therapeutic drug in patients with acute decompensated heart failure (ADHF) in clinical setting. METHODS AND RESULTS: Seven acute heart failure patients (74 +/- 5 years) with dyspnea and pulmonary congestion were studied. AM (0.02 microg x kg(-1) x min(-1)) + hANP (0.05 microg x kg(-1) x min(-1)) was infused for 12 h and then hANP (0.05 microg x kg(-1) x min(-1)) was infused for 12 h. Hemodynamic, renal, hormonal and oxidative stress responses were evaluated. AM + hANP significantly reduced mean arterial pressure, pulmonary arterial pressure and systemic and pulmonary vascular resistance without changing heart rate, and increased cardiac output for most time-points compared with those at baseline. In addition, AM + hANP reduced aldosterone, brain natriuretic peptide and free-radical metabolites compared with those at baseline (all P<0.05). AM + hANP increased urine volume and U(Na)V compared with baseline data. CONCLUSIONS: In this small, pilot trial, AM + hANP therapy had beneficial hemodynamic and hormonal effects in ADHF. Intravenous infusion of AM with hANP could be used as a therapeutic drug in ADHF. These data are preliminary and require confirmation in a larger clinical study. |
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Authors:
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Toshio Nishikimi; Tsuyoshi Karasawa; Chikako Inaba; Kimihiko Ishimura; Kazuyoshi Tadokoro; Shogo Koshikawa; Fumiki Yoshihara; Noritoshi Nagaya; Hideaki Sakio; Kenji Kangawa; Hiroaki Matsuoka |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-04-02 |
Journal Detail:
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Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 73 ISSN: 1346-9843 ISO Abbreviation: Circ. J. Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-04-24 Completed Date: 2009-08-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101137683 Medline TA: Circ J Country: Japan |
Other Details:
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Languages: eng Pagination: 892-8 Citation Subset: IM |
Affiliation:
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Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University, Mibu, Japan. nishikim@dokkyomed.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adrenomedullin / administration & dosage*, blood Aged Atrial Natriuretic Factor / administration & dosage*, blood Biological Markers / blood Cardiovascular Agents / administration & dosage*, blood Drug Administration Schedule Drug Therapy, Combination Female Heart Failure / blood, drug therapy*, physiopathology Hemodynamics / drug effects Humans Infusions, Intravenous Kidney / drug effects, physiopathology Male Oxidative Stress / drug effects Pilot Projects Time Factors Treatment Outcome Urodynamics / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Cardiovascular Agents; 148498-78-6/Adrenomedullin; 85637-73-6/Atrial Natriuretic Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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