| The effects of long- or medium-chain fat diets on glucose tolerance and myocellular content of lipid intermediates in rats. | |
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MedLine Citation:
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PMID: 20595951 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Accumulation of triacylglycerols (TAGs) and acylcarnitines in skeletal muscle upon high-fat (HF) feeding is the resultant of fatty acid uptake and oxidation and is associated with insulin resistance. As medium-chain fatty acids (MCFAs) are preferentially β-oxidized over long-chain fatty acids, we examined the effects of medium-chain TAGs (MCTs) and long-chain TAGs (LCTs) on muscle lipid storage and whole-body glucose tolerance. Rats fed a low-fat (LF), HFLCT, or an isocaloric HFMCT diet displayed a similar body weight gain over 8 weeks of treatment. Only HFLCT increased myocellular TAG (42.3 ± 4.9, 71.9 ± 6.7, and 48.5 ± 6.5 µmol/g for LF, HFLCT, and HFMCT, respectively, P < 0.05) and long-chain acylcarnitine content (P < 0.05). Neither HF diet increased myocellular diacylglycerol (DAG) content. Intraperitoneal (IP) glucose tolerance tests (1.5 g/kg) revealed a significantly decreased glucose tolerance in the HFMCT compared to the HFLCT-fed rats (802 ± 40, 772 ± 18, and 886 ± 18 area under the curve for LF, HFLCT, and HFMCT, respectively, P < 0.05). Finally, no differences in myocellular insulin signaling after bolus insulin injection (10 U/kg) were observed between LF, HFLCT, or HFMCT-fed rats. These results show that accumulation of TAGs and acylcarnitines in skeletal muscle in the absence of body weight gain do not impede myocellular insulin signaling or whole-body glucose intolerance. |
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Authors:
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Johan De Vogel-van den Bosch; Joris Hoeks; Silvie Timmers; Sander M Houten; Paul J van Dijk; Wendy Boon; Denis Van Beurden; Gert Schaart; Sander Kersten; Peter J Voshol; Ronald J A Wanders; Matthijs K Hesselink; Patrick Schrauwen |
Publication Detail:
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Type: Journal Article Date: 2010-07-01 |
Journal Detail:
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Title: Obesity (Silver Spring, Md.) Volume: 19 ISSN: 1930-7381 ISO Abbreviation: Obesity (Silver Spring) Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101264860 Medline TA: Obesity (Silver Spring) Country: United States |
Other Details:
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Languages: eng Pagination: 792-9 Citation Subset: IM |
Affiliation:
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1] Top Institute Food and Nutrition, Wageningen, The Netherlands [2] Department of Human Biology, NUTRIM, Maastricht University, Maastricht, The Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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