| Effects of Lipoprotein-Associated Phospholipase A2 on Arginase/Nitric Oxide Pathway in Hemodialysis Patients. | |
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MedLine Citation:
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PMID: 22583316 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Lipoprotein-associated phospholipase A2 (Lp-PLA2) and arginase are recently described inflammatory biomarkers associated with cardiovascular disease. In this study, we aimed to investigate the possible effects of serum Lp-PLA2 mass levels on arginase/nitric oxide (NO) pathway as a cardiovascular risk marker in hemodialysis (HD) patients. Forty-three HD patients and 15 healthy subjects were included in this study. Lipid profile, high sensitivity C-reactive protein (hs-CRP), albumin, creatinine, body mass index (BMI), Lp-PLA2 and total nitrite levels, and arginase activity were determined in serum samples from patients and control subjects. Lp-PLA2 levels were found to be positively correlated with arginase, triglycerides, total cholesterol, low-density lipoprotein-cholesterol, and age and negatively correlated with high-density lipoprotein-cholesterol and total nitrite levels, while there was no correlation with BMI and hs-CRP, albumin, and creatinine levels in HD patients. We conclude that elevated Lp-PLA2 mass levels may contribute to impaired arginase/NO pathway in HD patients and that increased the arginase activity and Lp-PLA2 mass levels with decreased total nitrite levels seem to be useful biochemical markers in terms of reflecting endothelial dysfunction and associated cardiovascular risks in HD patients. |
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Authors:
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Ayşegül Korkmaz Tektaş; Sema Uslu; Ahmet Uğur Yalçin; Garip Sahin; Gökhan Temiz; Mehmet Kara; Halide Edip Temel; Emine Sütken Demirkan; Ertuğrul Colak; Omer Colak |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-5-14 |
Journal Detail:
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Title: Renal failure Volume: - ISSN: 1525-6049 ISO Abbreviation: - Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-5-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8701128 Medline TA: Ren Fail Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Medical Biochemistry, School of Medicine, Unıiversity of Eskişehir Osmangazi , Eskişehir , Turkey. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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