Document Detail

Effects of lifestyle on micronuclei frequency in human lymphocytes in Japanese hard-metal workers.
MedLine Citation:
PMID:  19463494     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The risks of cardiovascular disease, cancer, and other major causes of mortality are largely attributable to lifestyle factors such as smoking, alcohol drinking, hours of working and sleeping, physical activity, diet, and stress. Earlier studies have suggested that an unhealthy lifestyle is also associated with increased lymphocyte sensitivity to mutagens, oxidative DNA damage level, and leukocyte DNA damage. In order to explore the genotoxicity of unhealthy lifestyle, we evaluated the effect of overall lifestyle as well as some individual lifestyle factors on micronuclei (MN) frequency in cultured human lymphocytes. METHOD: The study was conducted among 208 healthy adult (19 to 59 years) male Japanese hard-metal workers. The subjects were divided into groups according to their self-reported good, moderate, and poor lifestyles based on their responses to a questionnaire regarding eight health practices (cigarette smoking, alcohol consumption, sleeping hours, working hours, physical exercise, eating breakfast, balanced nutrition, and mental stress), the presence or absence of each of which was summed to obtain a health practice index (HPI: range 0-8). Peripheral blood was taken and the cytokinesis-block micronuclei (CBMN) assay was performed. RESULTS: Total lifestyle quality as measured by the HPI was strongly negatively associated with MN frequency in cultured human lymphocytes (p<0.01). Nutritional imbalance, lack of regular exercise (<2 times per week), insufficient sleep (< or =6 h per day), and overtime working (> or =9 h per day) each contributed significantly to higher MN frequency (all p<0.05). In the smoker group, a significantly higher MN frequency was only found in heavy smokers (p<0.05). On the other hand, mental stress, eating breakfast, and alcohol drinking had no effect on MN frequency. CONCLUSIONS: Taken together, these findings indicate that poor lifestyle habits significantly increase MN frequency in human lymphocytes.
Peixin Huang; Bin Huang; Huachun Weng; Kunio Nakayama; Kanehisa Morimoto
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-01-23
Journal Detail:
Title:  Preventive medicine     Volume:  48     ISSN:  1096-0260     ISO Abbreviation:  Prev Med     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2010-06-10     Completed Date:  2010-09-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0322116     Medline TA:  Prev Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  383-8     Citation Subset:  IM    
Department of Toxicology, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, P.R. China.
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MeSH Terms
Alcohol Drinking
Asian Continental Ancestry Group
Cross-Sectional Studies
Life Style*
Micronuclei, Chromosome-Defective*
Micronucleus Tests / methods*
Mutagenicity Tests
Reg. No./Substance:
0/Alloys; 0/hard metal; 7440-33-7/Tungsten; 7440-48-4/Cobalt

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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