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The Effects of Lidocaine Used in Sciatic Nerve on the Pharmacodynamics and Pharmacokinetics of Ropivacaine in Sciatic Nerve Combined with Lumbar Plexus Blockade: A Double-Blind, Randomized Study.
MedLine Citation:
PMID:  22985391     Owner:  NLM     Status:  Publisher    
In this controlled, randomized, double-blind study, we compared the pharmacodynamics and pharmacokinetics of ropivacaine and staged injection of lidocaine and ropivacaine in a combined lumbar plexus-sciatic nerve block. The experiment was performed in two parts: pharmacodynamics study (Group r, n=20; Group lr, n=20) and pharmacokinetics study (Group R, n=10; Group LR, n=10). The sciatic nerve blockade was performed using either 1) 10 mL of 2% lidocaine and then 10 mL of 0.75% ropivacaine (Group lr and Group LR) or 2) 10 mL of normal saline (N.S.) and then 10 mL of 0.75% ropivacaine (Group r and Group R). Two kinds of solutions were "staged" injection. The sensory onset time and sensory recovery time were assessed in the pharmacodynamics study. Arterial blood samples were collected for the pharmacokinetics study. Sciatic sensory block onset times were reduced and the sensory recovery times were decreased in Group lr. C(max) of ropivacaine in Group LR were significantly higher than in Group R. A significant increase in AUC((0-t)) and AUC((0-∞)) was observed in Group LR compared to Group R. When 2% lidocaine and 0.75% ropivacaine are used for a combined sciatic nerve-lumbar plexus block by "staged" injection, lidocaine induced faster onset times, decreased the block duration and increased the AUC and C(max) of ropivacaine.
Limei Chen; Quanguang Wang; Kejian Shi; Fuli Liu; Le Liu; Jianwu Ni; Xiangyu Fang; Xuzhong Xu
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-17
Journal Detail:
Title:  Basic & clinical pharmacology & toxicology     Volume:  -     ISSN:  1742-7843     ISO Abbreviation:  Basic Clin. Pharmacol. Toxicol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101208422     Medline TA:  Basic Clin Pharmacol Toxicol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors Basic & Clinical Pharmacology & Toxicology © 2012 Nordic Pharmacological Society.
Department of Anesthesiology, First Affiliated Hospital of Wenzhou Medical College, Zhejiang, China.
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