Document Detail


Effects of leptin deficiency and replacement on cerebellar response to food-related cues.
MedLine Citation:
PMID:  22576622     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Leptin affects eating behavior partly by altering the response of the brain to food-related stimuli. The effects of leptin on brain structure have been observed in the cerebellum, where leptin receptors are most densely expressed, but the function of leptin in the cerebellum remains unclear. We performed a nonrandomized, prospective interventional study of three adults with genetically mediated leptin deficiency. FMRI was recorded three times each year during years 5 and 6 of leptin replacement treatment. Session 1 of each year occurred after 10 months of continuous daily replacement, session 2 after 33-37 days without leptin, and session 3 at 14-23 days after daily replacement was restored. Statistical parametric mapping software (SPM5) was employed to contrast the fMRI blood oxygenation level-dependent response to images of high-calorie foods versus images of brick walls. Covariate analyses quantified the effects of the duration of leptin replacement and concomitant changes in body mass on the cerebral responses. Longer duration of replacement was associated with more activation by food images in a ventral portion of the posterior lobe of the cerebellum, while simultaneous decreases in body mass were associated with decreased activation in a more dorsal portion of the same lobe. These findings indicate that leptin replacement reversibly alters neural function within the posterior cerebellum and modulates plasticity-dependent brain physiology in response to food cues. The results suggest an underexplored role for the posterior cerebellum in the regulation of leptin-mediated processes related to food intake.
Authors:
Steven M Berman; Gilberto Paz-Filho; Ma-Li Wong; Milky Kohno; Julio Licinio; Edythe D London
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cerebellum (London, England)     Volume:  12     ISSN:  1473-4230     ISO Abbreviation:  Cerebellum     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-08     Completed Date:  2013-06-13     Revised Date:  2013-06-25    
Medline Journal Info:
Nlm Unique ID:  101089443     Medline TA:  Cerebellum     Country:  United States    
Other Details:
Languages:  eng     Pagination:  59-67     Citation Subset:  IM    
Affiliation:
Department of Psychiatry and Biobehavioral Sciences and the Semel Institute, David Geffen School of Medicine, University of California Los Angeles, 760 Westwood Plaza, C8-831, Los Angeles, CA 90024, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Appetite Regulation / drug effects,  physiology
Body Mass Index
Cerebellum / drug effects*,  physiology
Cues
Eating / drug effects*,  physiology
Energy Intake / drug effects,  physiology
Female
Hormone Replacement Therapy / methods*
Humans
Leptin / administration & dosage*,  deficiency*,  genetics
Magnetic Resonance Imaging
Male
Middle Aged
Neuronal Plasticity / drug effects,  physiology
Obesity / drug therapy*,  genetics,  physiopathology
Prospective Studies
Treatment Outcome
Grant Support
ID/Acronym/Agency:
K24 RR016996/RR/NCRR NIH HHS; K24 RR017365/RR/NCRR NIH HHS; K24RR016996/RR/NCRR NIH HHS; K24RR017365/RR/NCRR NIH HHS; M01 RR000865/RR/NCRR NIH HHS; M01RR00865/RR/NCRR NIH HHS; R01 DK058851/DK/NIDDK NIH HHS; R01 DK063240/DK/NIDDK NIH HHS; R01DK058851/DK/NIDDK NIH HHS; R01DK063240/DK/NIDDK NIH HHS; T32 DA024635/DA/NIDA NIH HHS; T32 DA024635/DA/NIDA NIH HHS; U01 GM061394/GM/NIGMS NIH HHS; U01GM061394/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Leptin
Comments/Corrections

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