Document Detail

Effects of Leontice smirnowii tuber monodesmosides and crude extract in carrageenan- and histamine-induced acute inflammation model of rats.
MedLine Citation:
PMID:  17085296     Owner:  NLM     Status:  MEDLINE    
Leontice smirnowii is a member of the Berberidaceae family. We have recently reported the 1,1-diphenyl-2-picryl-hydrazyl radical scavenging, superoxide anion radical scavenging, hydrogen peroxide scavenging, reducing power and metal chelating activities of L. smirnowii products. In the current study we investigated the possible effects of the crude extracts of L. smirnowii (CELS) and the monodesmoside's purified extract (MPE) of L. smirnowii in the carrageenan- and histamine-induced acute inflammation models in rats. The experiment revealed that CELS and MPE have anti-inflammatory effects, dose dependently in carrageenan-induced acute inflammation. On the other hand, their proinflammatory effects were surprisingly observed, especially in low doses, in the histamine-induced acute inflammation model. Summarizing these data, we may state that CELS and MPE exert their anti-inflammatory effects via non-histaminergic pathways.
A Gepdiremen; V Mshvildadze; K Bakuridze; R Elias
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-11-02
Journal Detail:
Title:  Phytomedicine : international journal of phytotherapy and phytopharmacology     Volume:  13     ISSN:  0944-7113     ISO Abbreviation:  Phytomedicine     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-11-06     Completed Date:  2007-02-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9438794     Medline TA:  Phytomedicine     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  728-31     Citation Subset:  IM    
Faculty of Medicine, Department of Pharmacology, Ondokuz Mayis University, TR-55139-Kurupelit Samsun, Turkey.
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MeSH Terms
Anti-Inflammatory Agents / analysis,  therapeutic use*
Berberidaceae / chemistry*
Inflammation / drug therapy*
Plant Extracts / chemistry,  therapeutic use
Plant Tubers / chemistry
Rats, Wistar
Saponins / isolation & purification,  therapeutic use*
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Plant Extracts; 0/Saponins; 51-45-6/Histamine; 9000-07-1/Carrageenan

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