Document Detail


The effects of lactulose supplementation to enteral feedings in premature infants: a pilot study.
MedLine Citation:
PMID:  19879595     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To assess the safety and prebiotic effects of lactulose in preterm infants. STUDY DESIGN: This was a prospective, double-blinded, placebo-controlled, single-center study in 23- to 34-weeks premature infants. The study group received 1% lactulose, and control infants received 1% dextrose in all feeds (human milk or formula). RESULTS: Twenty-eight infants participated (15 lactulose, 13 placebo). Small doses of lactulose appeared to be safe and did not cause diarrhea. Premature infants on lactulose had more Lactobacilli-positive stool cultures that appeared earlier with larger number of colonies. The lactulose group tended to have less intolerance to enteral feedings, to reach full oral feeds earlier, and to be discharged home earlier. They also tended to have fewer episodes of late-onset sepsis, lower Bell stage necrotizing enterocolitis, and their nutritional laboratory indices were better, especially calcium and total protein. CONCLUSIONS: This pilot study supports the safety of supplementing preterm infants' feeds with low doses of lactulose. It also demonstrated trends that may suggest positive prebiotic effects.
Authors:
Arieh Riskin; Ori Hochwald; David Bader; Isaac Srugo; Gabi Naftali; Amir Kugelman; Ella Cohen; Frida Mor; Bela Kaufman; Ron Shaoul
Related Documents :
18422595 - Human milk fortification and gastric emptying in the preterm neonate.
2282025 - Long-segmented filamentous organisms observed in poults experimentally infected with st...
10804895 - Feeding and non-feeding interactions of mothers and prematures.
19948525 - Prospective study of non-nutritive sucking and feeding skills in premature infants.
17130415 - Abnormal orbitofrontal development due to prematurity.
19539995 - M-ficolin in the neonatal period: associations with need for mechanical ventilation and...
Publication Detail:
Type:  Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial     Date:  2009-10-31
Journal Detail:
Title:  The Journal of pediatrics     Volume:  156     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-28     Completed Date:  2010-02-23     Revised Date:  2010-07-21    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  209-14     Citation Subset:  AIM; IM    
Copyright Information:
Copyright 2010 Mosby, Inc. All rights reserved.
Affiliation:
Department of Neonatology, Bnai Zion Medical Center, Technion, Israel Institute of Technology, 47 Golomb Street, POB 4940, Haifa 31048, Israel. arik.riskin@b-zion.org.il
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Colony Count, Microbial
Double-Blind Method
Enteral Nutrition*
Female
Gastrointestinal Agents / administration & dosage,  therapeutic use*
Humans
Infant, Newborn
Infant, Premature*
Lactobacillus / growth & development
Lactulose / administration & dosage,  therapeutic use*
Male
Pilot Projects
Prebiotics* / adverse effects
Prospective Studies
Safety
Chemical
Reg. No./Substance:
0/Gastrointestinal Agents; 0/Prebiotics; 4618-18-2/Lactulose
Comments/Corrections
Comment In:
J Pediatr. 2010 Aug;157(2):347   [PMID:  20542288 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Dilated cardiomyopathy in children with ventricular preexcitation: the location of the accessory pat...
Next Document:  Colesevelam hydrochloride: efficacy and safety in pediatric subjects with heterozygous familial hype...