| The effects of lactulose supplementation to enteral feedings in premature infants: a pilot study. | |
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MedLine Citation:
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PMID: 19879595 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess the safety and prebiotic effects of lactulose in preterm infants. STUDY DESIGN: This was a prospective, double-blinded, placebo-controlled, single-center study in 23- to 34-weeks premature infants. The study group received 1% lactulose, and control infants received 1% dextrose in all feeds (human milk or formula). RESULTS: Twenty-eight infants participated (15 lactulose, 13 placebo). Small doses of lactulose appeared to be safe and did not cause diarrhea. Premature infants on lactulose had more Lactobacilli-positive stool cultures that appeared earlier with larger number of colonies. The lactulose group tended to have less intolerance to enteral feedings, to reach full oral feeds earlier, and to be discharged home earlier. They also tended to have fewer episodes of late-onset sepsis, lower Bell stage necrotizing enterocolitis, and their nutritional laboratory indices were better, especially calcium and total protein. CONCLUSIONS: This pilot study supports the safety of supplementing preterm infants' feeds with low doses of lactulose. It also demonstrated trends that may suggest positive prebiotic effects. |
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Authors:
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Arieh Riskin; Ori Hochwald; David Bader; Isaac Srugo; Gabi Naftali; Amir Kugelman; Ella Cohen; Frida Mor; Bela Kaufman; Ron Shaoul |
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Publication Detail:
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Type: Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial Date: 2009-10-31 |
Journal Detail:
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Title: The Journal of pediatrics Volume: 156 ISSN: 1097-6833 ISO Abbreviation: J. Pediatr. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-28 Completed Date: 2010-02-23 Revised Date: 2010-07-21 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: United States |
Other Details:
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Languages: eng Pagination: 209-14 Citation Subset: AIM; IM |
Copyright Information:
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Copyright 2010 Mosby, Inc. All rights reserved. |
Affiliation:
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Department of Neonatology, Bnai Zion Medical Center, Technion, Israel Institute of Technology, 47 Golomb Street, POB 4940, Haifa 31048, Israel. arik.riskin@b-zion.org.il |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Colony Count, Microbial Double-Blind Method Enteral Nutrition* Female Gastrointestinal Agents / administration & dosage, therapeutic use* Humans Infant, Newborn Infant, Premature* Lactobacillus / growth & development Lactulose / administration & dosage, therapeutic use* Male Pilot Projects Prebiotics* / adverse effects Prospective Studies Safety |
| Chemical | |
Reg. No./Substance:
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0/Gastrointestinal Agents; 0/Prebiotics; 4618-18-2/Lactulose |
| Comments/Corrections | |
Comment In:
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J Pediatr. 2010 Aug;157(2):347
[PMID:
20542288
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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