Document Detail


Effects of Lactobacillus strains on cancer cell proliferation and oxidative stress in vitro.
MedLine Citation:
PMID:  16620202     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: The objective of this study was to assess in vitro, whether heat-killed (HK) lactic acid bacteria cells and fractionations of HK cells could suppress the viability of human cancer cells and inhibit the cytotoxicity associated with oxidative stress. METHODS AND RESULTS: Among the strains, the HK cells of Lactobacillus acidophilus 606 and Lactobacillus casei ATCC 393 exhibited the most profound inhibitory activity in all of the tested cell lines. HK cells of L. acidophilus 606 were determined to be less toxic to healthy human embryo fibroblasts (hEF cells) than were HK cells of L. casei ATCC 393. The soluble polysaccharides from L. acidophilus 606 evidenced the most effective anticancer activity, but inhibited hEF cell growth by only 20%. The soluble polysaccharides from L. acidophilus 606 were partly observed to induce apoptosis in the HT-29 cells by DNA fragmentation and propidium iodine staining. Both the HK cells of L. acidophilus 606 and the soluble polysaccharide components of this strain also exhibited potent antioxidative activity. CONCLUSIONS: Our findings suggest that the soluble polysaccharide fraction from L. acidophilus 606 may constitute a novel anticancer agent, which manifests a high degree of selectivity for human cancer cells and antioxidative agent in the food industry. SIGNIFICANCE AND IMPACT OF THE STUDY: These soluble polysaccharide components from Lactobacillus may be applied to various foods, and used as adjuncts for cancer therapy and prevention.
Authors:
S S Choi; Y Kim; K S Han; S You; S Oh; S H Kim
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Letters in applied microbiology     Volume:  42     ISSN:  0266-8254     ISO Abbreviation:  Lett. Appl. Microbiol.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-04-19     Completed Date:  2006-07-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8510094     Medline TA:  Lett Appl Microbiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  452-8     Citation Subset:  IM    
Affiliation:
Division of Food Science, Korea University, Seoul, South Korea.
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents / pharmacology*
Antioxidants / pharmacology*
Apoptosis
Cell Line, Tumor
Cell Proliferation* / drug effects
Cell Survival / drug effects
DNA Fragmentation
Humans
Lactobacillus* / chemistry
Lactobacillus acidophilus / chemistry
Lactobacillus casei / chemistry
Microscopy, Fluorescence
Oxidative Stress* / drug effects
Polysaccharides, Bacterial / pharmacology*
Propidium / metabolism
Staining and Labeling
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Antioxidants; 0/Polysaccharides, Bacterial; 36015-30-2/Propidium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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