| Effects of Lactic Acid-Fermented Soymilk on Lipid Metabolism-Related Gene Expression in Rat Liver. | |
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MedLine Citation:
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PMID: 22232236 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We examined the effects of lactic acid fermentation of soymilk on the lipid profile and lipid metabolism-related gene expression in rat liver. Male Sprague-Dawley rats aged 7 weeks were fed a control diet (AIN-93), soymilk diet, or fermented soymilk diet for 1 week or 5 weeks. The hepatic triglyceride and cholesterol contents in the soymilk (SM) group and the fermented soymilk (FSM) group were significantly lower than those in the control group after 5 weeks, but these changes had not become apparent until after 1 week. The fatty acid synthesis-related genes were more markedly down-regulated after 1 week than after 5 weeks, whereas the cytochrome p450 family 7 subfamily a polypeptide 1 (CYP7al) gene related to cholesterol catabolism was more markedly up-regulated after 5 weeks than after 1 week. This up-regulation was higher in the FSM group than in the SM group. It is assumed that the bioactive components produced by lactic acid fermentation induced the up-regulation of CYP7a1. |
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Authors:
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Maki Kobayashi; Tomoko Harada; Naohiro Takagi; Kimiko Tsuzuki; Makoto Sugawara; Mitsuru Fukuda |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-7 |
Journal Detail:
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Title: Bioscience, biotechnology, and biochemistry Volume: - ISSN: 1347-6947 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9205717 Medline TA: Biosci Biotechnol Biochem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Food Science and Nutrition, School of Human Environmental Sciences, Mukogawa Women's University. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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