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Effects of LNG-IUS on nerve growth factor and its receptors expression in patients with adenomyosis.
MedLine Citation:
PMID:  20854189     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
The levonorgestrel-releasing intrauterine system (LNG-IUS) is effective in the treatment of dysmenorrhea associated with adenomyosis. However, the mechanism of pain relief of LNG-IUS in patients with adenomyosis is unclear. We aimed to investigate the effects of LNG-IUS on the expression of nerve growth factor (NGF) and its receptors, NGFR p75 and TrkA in patients with adenomyosis. Endometrial and myometrial tissues were prepared from 17 LNG-IUS-treated patients and 15 hormonally untreated patients who had undergone hysterectomies for adenomyosis. Immunohistochemistry with antibodies against NGF, NGFR p75, and TrkA, was performed. The expression of NGF, NGFR p75, and TrkA in endometrium and myometrium of LNG-IUS-treated patients was significantly decreased compared to those of hormonally untreated patients. Our findings may indicate that the suppression of NGF and its receptors by LNG-IUS is another possible mechanism of relieving pain in patients with adenomyosis.
Authors:
Young Sik Choi; Sihyun Cho; Kyung Jin Lim; Young Eun Jeon; Hyo In Yang; Kyung Eun Lee; Kamdar Heena; Seok Kyo Seo; Hye Yeon Kim; Byung Seok Lee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-09-21
Journal Detail:
Title:  Growth factors (Chur, Switzerland)     Volume:  28     ISSN:  1029-2292     ISO Abbreviation:  Growth Factors     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9000468     Medline TA:  Growth Factors     Country:  England    
Other Details:
Languages:  eng     Pagination:  452-60     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Severance Hospital, Yonsei University College of Medicine, Shinchon-dong, Seodaemun-gu, Seoul, South Korea.
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