| Effects of L-glutamate on the responses to nerve stimulation in rat isolated atria. | |
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MedLine Citation:
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PMID: 7522178 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In rat atria isolated with their sympathetic fibres the chronotropic responses to nerve stimulation with pulses of 2 ms duration were reduced in a concentration-dependent manner by 10 microM to 1 mM L-glutamate (Glu) and by 0.01 to 1.00 microM (R,S)-3-hydroxy-5-methoxyloxasole-4-propionic acid (AMPA), whereas they were unaffected by other agonists of Glu receptors such as 1 microM to 1 mM N-methyl-D-aspartic acid (NMDA), 10 microM to 1 mM kainate and 1 to 100 microM (+/-)-2-amino-4-phosphonobutyric acid (AP4). The reductions in the atrial responses to nerve stimulation caused by Glu were not accompanied by alterations in either the basal efflux of [3H]noradrenaline or its overflow in response to the stimulation. The sensitivity of the atria to exogenous noradrenaline was not modified by either Glu or AMPA. The decreases in the chronotropic responses caused by Glu and by AMPA were prevented by both the non-selective Glu receptor antagonist, 100 microM kynurenic acid, and the selective AMPA receptor antagonist, 10 to 50 microM 6,7-dinitroquinoxaline-2,3-dione (DNQX). In addition, the adenosine receptor antagonist, 8-phenyltheophylline (10 microM), as well as the muscarinic acetylcholine receptor antagonist, atropine (3 microM), prevented the inhibitory effects of both Glu and AMPA on the chronotropic responses of rat isolated atria. Since both adenosine and acetylcholine are known to exert negative inotropic and chronotropic effects in cardiac tissues, it is proposed that Glu could contribute, through the interaction with receptors of the AMPA type, to facilitate the release of adenosine and acetylcholine from the atria.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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P S Lorenzo; N V Butta; E Adler-Graschinsky |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of pharmacology Volume: 258 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1994 Jun |
Date Detail:
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Created Date: 1994-10-19 Completed Date: 1994-10-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 253-60 Citation Subset: IM |
Affiliation:
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Instituto de Investigaciones Farmacológicas, CONICET, Buenos Aires, Argentina. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic Fibers
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physiology* Aminobutyric Acids / pharmacology Animals Atrial Function Electric Stimulation Female Glutamates / pharmacology* Glutamic Acid Heart Atria / drug effects*, innervation Heart Rate / drug effects* Kainic Acid / pharmacology Male Muscarinic Antagonists N-Methylaspartate / pharmacology Norepinephrine / metabolism Quinoxalines / pharmacology Rats Rats, Wistar Receptors, Purinergic P1 / antagonists & inhibitors alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Aminobutyric Acids; 0/Glutamates; 0/Muscarinic Antagonists; 0/Quinoxalines; 0/Receptors, Purinergic P1; 2379-57-9/FG 9041; 487-79-6/Kainic Acid; 51-41-2/Norepinephrine; 56-86-0/Glutamic Acid; 6323-99-5/2-amino-4-phosphonobutyric acid; 6384-92-5/N-Methylaspartate; 77521-29-0/alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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