Document Detail

Effects of L-citrulline oral supplementation on polymorphonuclear neutrophils oxidative burst and nitric oxide production after exercise.
MedLine Citation:
PMID:  19585317     Owner:  NLM     Status:  MEDLINE    
Seventeen volunteer male professional cyclists were randomly assigned to control or supplemented (6 g L-citrulline-malate) groups and participated in a cycling stage. Blood samples were taken in basal conditions, after the race and 3 h post-race. Citrulline supplementation significantly increased plasma concentration of both arginine and citrulline after the stage only in the supplemented group. Polymorphonuclear neutrophils (PMNs) from controls responded to exercise with a progressive decrease in ROS production. Supplemented PMNs significantly increased ROS production after exercise compared to basal values and diminished to values lower than basal at recovery. PMN nitrite concentration was significantly higher after exercise and recovery only in the supplemented group. Markers of oxidative damage-CK, LDH, malondialdehyde-and DNA damage remained unchanged in both groups. In conclusion, oral L-citrulline administration previous to a cycling stage increases plasma arginine availability for NO synthesis and PMNs priming for oxidative burst without oxidative damage.
Antoni Sureda; Alfredo Cordova; Miguel D Ferrer; Pedro Tauler; Gerardo Perez; Josep A Tur; Antoni Pons
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2009-07-06
Journal Detail:
Title:  Free radical research     Volume:  43     ISSN:  1029-2470     ISO Abbreviation:  Free Radic. Res.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-17     Completed Date:  2009-09-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423872     Medline TA:  Free Radic Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  828-35     Citation Subset:  IM    
Laboratori de Ciencies de l'Activitat Fisica, Departament de Biologia Fonamental i Ciencies de la Salut, Universitat de les Illes Balears, Palma de Mallorca, Illes Balears, Spain.
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MeSH Terms
Administration, Oral
Arginine / blood
Citrulline / administration & dosage,  analogs & derivatives*,  blood
Creatine Kinase / blood
DNA Damage
Dietary Supplements*
Double-Blind Method
L-Lactate Dehydrogenase / blood
Malates / administration & dosage*,  blood
Malondialdehyde / blood
Neutrophil Activation / drug effects*
Neutrophils / drug effects*,  metabolism
Nitric Oxide / blood*
Nitrites / blood
Respiratory Burst / drug effects*
Time Factors
Young Adult
Reg. No./Substance:
0/Malates; 0/Nitrites; 10102-43-9/Nitric Oxide; 372-75-8/Citrulline; 542-78-9/Malondialdehyde; 54940-97-5/citrulline malate; 74-79-3/Arginine; EC Dehydrogenase; EC Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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