Document Detail

Effects of L-aspartate and oxaloacetic acid on click-evoked cochlear potentials.
MedLine Citation:
PMID:  2870048     Owner:  NLM     Status:  MEDLINE    
The scala tympani of the guinea pig was perfused with artificial perilymph and experimental solutions using an electrical micropump. In test perfusions, 20 mM L-aspartate produced depression of APN1 by 49% and 25 mM L-aspartate decreased the amplitude of APN1 by 42%. Both 20 mM and 25 mM L-aspartate were without effect on the CM, the latency or width of APN1. Perfusions with 10 mM oxaloacetic acid were without effect on the APN1 and CM. In our previous experiments, 5 mM L-aspartate had no effect on APN1 and CM, but 10 mM L-aspartate or 15 mM L-aspartate introduced into the scala tympani reversibly increased the amplitude of APN1 and CM. It is concluded that L-aspartate may have a modulating influence on signal transmission of afferent synapses in the cochlea.
Y W Sun; Y X Zhou; D P Ding
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hearing research     Volume:  21     ISSN:  0378-5955     ISO Abbreviation:  Hear. Res.     Publication Date:  1986  
Date Detail:
Created Date:  1986-04-25     Completed Date:  1986-04-25     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  7900445     Medline TA:  Hear Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  83-6     Citation Subset:  IM    
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MeSH Terms
Action Potentials / drug effects
Aspartic Acid / pharmacology*
Cochlear Microphonic Potentials / drug effects*
Evoked Potentials, Auditory / drug effects*
Guinea Pigs
Neurons, Afferent / drug effects
Neurotransmitter Agents*
Oxaloacetates / pharmacology*
Oxaloacetic Acids
Reaction Time / drug effects
Synaptic Membranes / drug effects
Reg. No./Substance:
0/Neurotransmitter Agents; 0/Oxaloacetates; 0/Oxaloacetic Acids; 56-84-8/Aspartic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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