Document Detail

Effects of L-arginine on angiotensin II-related water and salt intakes.
MedLine Citation:
PMID:  9523923     Owner:  NLM     Status:  MEDLINE    
Nitric oxide (NO) has been implicated centrally as an inhibitory neuromodulator, acting in short feedback loops. Neurons capable of NO synthesis have been localized in various thirst-related hypothalamic nuclei. Intracerebroventricular (icv) injection of L-arginine (L-arg), the precursor for NO, has previously been shown to attenuate both dehydration- and angiotensin II (Ang II)-induced drinking behavior. The present study further examines the effects of L-arg on drinking. We confirmed that icv administration of L-arg (50 microg) reduced water intakes induced by both 24 h water deprivation and icv Ang II (250 ng). We additionally showed that L-arg inhibited the water intake induced by peripheral injection of Ang II and the intake of 0.3 M NaCl following 24 h sodium depletion. We demonstrated the behavioral specificity of L-arg treatment by showing that it did not inhibit the intake of sucrose in food deprived rats and did not act as an unconditional stimulus for the formation of a conditioned taste aversion. These results lend further support to the idea that NO plays a role in modulating fluid balance and drinking behavior.
J D Roth; N E Rowland
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Physiology & behavior     Volume:  63     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-05-21     Completed Date:  1998-05-21     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  729-32     Citation Subset:  IM    
Department of Psychology, University of Florida, Gainesville 32611-2250, USA.
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MeSH Terms
Angiotensin II / administration & dosage,  pharmacology*
Arginine / administration & dosage,  pharmacology*
Diuretics / pharmacology
Drinking / drug effects*
Food Deprivation / physiology
Food Preferences / drug effects*
Furosemide / pharmacology
Injections, Intraventricular
Injections, Subcutaneous
Rats, Sprague-Dawley
Sodium / physiology
Sodium, Dietary
Water Deprivation / physiology
Reg. No./Substance:
0/Diuretics; 0/Sodium, Dietary; 11128-99-7/Angiotensin II; 54-31-9/Furosemide; 74-79-3/Arginine; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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