| Effects of L-NAME on thromboxane A2-induced venoconstriction in isolated perfused livers from rat, guinea pig and mouse. | |
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MedLine Citation:
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PMID: 17662668 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Effects of L-NAME on U-46619 (a thromboxane A(2), analogue) -induced hepatic segmental venoconstriction were examined in mouse, rat and guinea pig isolated perfused livers. All livers were perfused portally and recirculatingly at a constant flow with diluted blood. U-46619 was administrated into the reservoir in a cumulative manner to gain the concentrations of 0.001-3 microM at 10 min after L-NAME or D-NAME (100 microM). The portal venous pressure, hepatic venous pressure and perfusate flow were monitored. In addition, the sinusoidal pressure was measured by the double occlusion pressure, and was used to determine the pre- (Rpre) and post-sinusoidal (Rpost) resistances. U-46619 concentration-dependently caused predominant presinusoidal constriction in all three species. The rat livers were the strongest while the mouse livers were the weakest in responsiveness and sensitivity to U-46619. L-NAME mainly augmented the U-46619-induced increases in Rpre, but not in Rpost, in rat and guinea pig. This augmentation was stronger in rat. However, L-NAME did not augment the response to U-46619 in mouse. In conclusion, in rat and guinea pig, NO may be released selectively from the presinusoids in response to U-46619, and then attenuate the U-46619-induced presinusoidal constriction. In mouse, U-46619-induced venoconstriction is weak and not modulated by NO. |
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Authors:
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Sen Cui; Toshishige Shibamoto; Zhansheng Zhao; Wei Zhang; Hiromichi Takano; Yasutaka Kurata |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-06-27 |
Journal Detail:
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Title: Vascular pharmacology Volume: 47 ISSN: 1537-1891 ISO Abbreviation: Vascul. Pharmacol. Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-10-01 Completed Date: 2008-01-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101130615 Medline TA: Vascul Pharmacol Country: United States |
Other Details:
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Languages: eng Pagination: 215-21 Citation Subset: IM |
Affiliation:
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Department of Physiology, Kanazawa Medical University, Uchinada 920-0293, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
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pharmacology* Animals Guinea Pigs Hepatic Veins / physiology Liver Circulation / drug effects* Male Mice NG-Nitroarginine Methyl Ester / pharmacology* Nitric Oxide / biosynthesis Perfusion Portal Vein / physiology Rats Rats, Sprague-Dawley Vasoconstriction / drug effects* |
| Chemical | |
Reg. No./Substance:
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10102-43-9/Nitric Oxide; 50903-99-6/NG-Nitroarginine Methyl Ester; 76898-47-0/15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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