Document Detail

Effects of L- and DL-carnitine on patients with impaired exercise tolerance.
MedLine Citation:
PMID:  7650839     Owner:  NLM     Status:  MEDLINE    
We designed this study to determine whether orally administered L- and DL-carnitine can improve exercise tolerance in a group of patients with exercise intolerance. Nineteen patients with cardiac disease were randomly divided into 2 groups, an L-carnitine treatment group (n = 9) and a DL-carnitine treatment group (n = 10). Eight additional age-matched patients served as an untreated control group. Subjects in both carnitine treatment groups underwent cardiopulmonary exercise testing on a cycle ergometer in order to determine peak exercise time, peak oxygen uptake (VO2), lactate threshold (LT) and ventilatory threshold (VT) before and after the oral administration of 900 mg/day of L- or DL-carnitine for 2 weeks. Basal values of peak exercise time, peak VO2, LT and VT did not differ significantly among the 3 groups. Peak exercise time and peak VO2 tended to be increased in the L-carnitine treatment group, and tended to be decreased in the DL-carnitine treatment group. Both LT and VT (ml/kg/min) were significantly improved (LT: from 9.7 +/- 0.6 to 10.8 +/- 1.0, p < 0.05; VT: from 9.8 +/- 0.8 to 11.8 +/- 1.9, p < 0.02) by the administration of L-carnitine, while LT was significantly decreased (from 11.0 +/- 2.0 to 9.6 +/- 1.2, p < 0.05) and VT tended to be decreased by the administration of DL-carnitine (from 11.6 +/- 2.0 to 10.8 +/- 2.4). In the untreated control group, no significant changes were observed in the values of exercise tolerance between the 2 series of exercise testings. In neither group did carnitine modify hemodynamic parameters at rest or during exercise. In conclusion, this study demonstrated that L-carnitine increases and DL-carnitine decreases exercise tolerance in patients with impaired exercise tolerance.
S Watanabe; R Ajisaka; T Masuoka; T Yamanouchi; T Saitou; M Toyama; N Takeyasu; K Sakamoto; Y Sugishita
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Japanese heart journal     Volume:  36     ISSN:  0021-4868     ISO Abbreviation:  Jpn Heart J     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-09-26     Completed Date:  1995-09-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0401175     Medline TA:  Jpn Heart J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  319-31     Citation Subset:  IM    
Department of Internal Medicine, University of Tsukuba, Japan.
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MeSH Terms
Administration, Oral
Cardiac Output / drug effects
Carnitine / administration & dosage,  pharmacology*
Exercise Test
Exercise Tolerance / drug effects*
Heart Diseases / drug therapy,  physiopathology
Hemodynamics / drug effects*
Lactates / metabolism
Lactic Acid
Middle Aged
Oxygen Consumption / drug effects
Pyruvates / metabolism
Pyruvic Acid
Reg. No./Substance:
0/Lactates; 0/Pyruvates; 127-17-3/Pyruvic Acid; 50-21-5/Lactic Acid; 541-15-1/Carnitine

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