Document Detail

Effects of L-2-oxothiazolidine-4-carboxylate, a cysteine pro-drug, on teratogenicity of 5-fluorouracil in mice.
MedLine Citation:
PMID:  2283306     Owner:  NLM     Status:  MEDLINE    
Embryotoxicity and teratogenicity of 5-fluorouracil (5-FU) and modulation of its effect by L-2-oxothiazolidine-4-carboxylate (OTC), a cysteine pro-drug, were evaluated in mice. Pregnant ICR mice were intraperitoneally (i.p.) injected with 25 mg/kg of 5-FU on day 11 of gestation (vaginal plug = day 0). Mice were pretreated i.p. with 950 mg/kg of OTC 4 hours before dosing with 5-FU. Dams were killed on day 17 of gestation. Fetuses were examined for external malformations, especially limb malformations. Pretreatment with OTC decreased the frequency and severity of oligodactyly induced by 5-FU, although the differences were not significant statistically. There was little difference in either liver glutathione levels, or body weight gain during gestation of dams between the 5-FU group and the 5-FU plus OTC group. Fetal mortality and fetal weight of the group treated with 5-FU alone were comparable with those of the group pretreated with OTC. In the present study, teratogenicity of 5-FU seemed to be slightly mitigated with OTC pretreatment.
M Naya; M Noguchi; Y Mataki; T Deguchi; M Yasuda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hiroshima journal of medical sciences     Volume:  39     ISSN:  0018-2052     ISO Abbreviation:  Hiroshima J. Med. Sci.     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1991-03-18     Completed Date:  1991-03-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0421060     Medline TA:  Hiroshima J Med Sci     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  79-82     Citation Subset:  IM    
Kyowa Toxicological Research Laboratories, Yamaguchi, Japan.
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MeSH Terms
Body Weight / drug effects
Cystine / metabolism
Drug Synergism
Fluorouracil / toxicity*
Glutathione / metabolism
Limb Deformities, Congenital
Liver / drug effects,  metabolism
Maternal-Fetal Exchange
Mice, Inbred ICR
Pyrrolidonecarboxylic Acid
Thiazoles / pharmacology*
Reg. No./Substance:
0/Thiazoles; 0/Thiazolidines; 19750-45-9/2-oxothiazolidine-4-carboxylic acid; 51-21-8/Fluorouracil; 56-89-3/Cystine; 70-18-8/Glutathione; 98-79-3/Pyrrolidonecarboxylic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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