| Effects of Kaempferia parviflora extracts on reproductive parameters and spermatic blood flow in male rats. | |
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MedLine Citation:
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PMID: 18614624 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Krachaidum (KD, Kaempferia parviflora Wall. Ex. Baker), a native plant of Southeast Asia, is traditionally used to enhance male sexual function. However, only few scientific data in support of this anecdote have been reported. The present study investigated the effects of feeding three different extracts of KD (alcohol, hexane, and water extracts) for 3-5 weeks on the reproductive organs, the aphrodisiac activity, fertility, sperm motility, and blood flow to the testis of male rats. Sexual performances (mount latency, mount frequency, ejaculatory latency, post-ejaculatory latency) and sperm motility were assessed by a video camera and computer-assisted sperm analysis respectively, while blood flow to the testis was measured by a directional pulsed Doppler flowmeter. The results showed that all extracts of KD had virtually no effect on the reproductive organ weights even after 5 weeks. However, administration of the alcohol extract at a dose of 70 mg/kg body weight (BW)/day for 4 weeks significantly decreased mount and ejaculatory latencies when compared with the control. By contrast, hexane and water extracts had no influence on any sexual behavior parameters. All types of extracts of KD had no effect on fertility or sperm motility. On the other hand, alcohol extract produced a significant increase in blood flow to the testis without affecting the heart rate and mean arterial blood pressure. In a separate study, an acute effect of alcohol extract of KD on blood flow to the testis was investigated. Intravenous injection of KD at doses of 10, 20, and 40 mg/kg BW caused dose-dependent increases in blood flow to the testis. The results indicate that alcohol extract of KD had an aphrodisiac activity probably via a marked increase in blood flow to the testis. |
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Authors:
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G Chaturapanich; S Chaiyakul; V Verawatnapakul; C Pholpramool |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-07-09 |
Journal Detail:
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Title: Reproduction (Cambridge, England) Volume: 136 ISSN: 1741-7899 ISO Abbreviation: Reproduction Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-09-17 Completed Date: 2008-12-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100966036 Medline TA: Reproduction Country: England |
Other Details:
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Languages: eng Pagination: 515-22 Citation Subset: IM |
Affiliation:
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Department of Physiology, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aphrodisiacs / isolation & purification, pharmacology* Ethanol Female Fertility / drug effects Hexanes Laser-Doppler Flowmetry Male Plant Extracts / isolation & purification, pharmacology* Rats Rats, Sprague-Dawley Regional Blood Flow / drug effects Reproduction / drug effects* Sexual Behavior, Animal / drug effects Sperm Motility / drug effects Testis / blood supply* Video Recording Water Zingiberaceae* |
| Chemical | |
Reg. No./Substance:
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0/Aphrodisiacs; 0/Hexanes; 0/Plant Extracts; 64-17-5/Ethanol; 7732-18-5/Water |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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