| Effects of K(+) channel inhibitors on relaxation induced by flufenamic and tolfenamic acids in guinea-pig trachea. | |
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MedLine Citation:
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PMID: 10585531 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of different K(+) channel inhibitors on flufenamic- and tolfenamic-acids-induced relaxation were studied in prostaglandin F(2alpha) (1 microM) precontracted guinea-pig trachea. Flufenamic and tolfenamic acids (each 0.1-33 microM) and lemakalim (0.01-33 microM), but not indomethacin (0.1-33 microM), caused relaxation. Iberiotoxin (33 and 100 nM) inhibited flufenamic- and tolfenamic-acids-, but not lemakalim-, induced relaxation. Iberiotoxin (100 nM) inhibited nifedipine (10 nM-10 microM)-induced relaxation. Nifedipine (0.1 microM) inhibited the blockade of fenamate-induced relaxation by iberiotoxin. Apamin (0.1 and 1 microM) did not affect flufenamic- and tolfenamic-acids- and lemakalim-induced relaxation. Glibenclamide (10 and 33 microM) inhibited lemakalim-, but not flufenamic- and tolfenamic-acids-, induced relaxation. 4-Aminopyridine (0.5 and 2 mM) inhibited flufenamic- and tolfenamic- acids- and lemakalim-induced relaxation. Flufenamic- and tolfenamic-acids-induced relaxation is likely to be activation of Ca(2+)-activated K(+) channels and differs from that of lemakalim. |
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Authors:
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L Li; K Vaali; H Vapaatalo; H Kankaanranta |
Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of pharmacology Volume: 383 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1999 Oct |
Date Detail:
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Created Date: 2000-02-03 Completed Date: 2000-02-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 169-76 Citation Subset: IM |
Affiliation:
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Institute of Biomedicine, Department of Pharmacology and Toxicology, P.O. Box 8, University of Helsinki, Helsinki, Finland. liangli@ruby.iupui.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anthranilic Acids / antagonists & inhibitors*, pharmacology Anti-Inflammatory Agents, Non-Steroidal / antagonists & inhibitors*, pharmacology Calcium Channel Blockers / pharmacology Calcium Channels, L-Type / drug effects Cromakalim / pharmacology Dinoprost / pharmacology Female Flufenamic Acid / antagonists & inhibitors*, pharmacology Guinea Pigs Indomethacin / pharmacology Male Muscle Relaxation / drug effects Nifedipine / pharmacology Potassium Channel Blockers* Potassium Channels / agonists Trachea / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Anthranilic Acids; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Calcium Channel Blockers; 0/Calcium Channels, L-Type; 0/Potassium Channel Blockers; 0/Potassium Channels; 13710-19-5/tolfenamic acid; 21829-25-4/Nifedipine; 53-86-1/Indomethacin; 530-78-9/Flufenamic Acid; 551-11-1/Dinoprost; 94470-67-4/Cromakalim |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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