| Effects of Japanese herbal medicine, Juzen-taiho-to, in otitis-prone children--a preliminary study. | |
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MedLine Citation:
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PMID: 18608005 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONCLUSION: Juzen-taiho-to (JTT, TJ-48), a Japanese herbal medicine that improves immune function, was found to be effective in otitis-prone in children. OBJECTIVE: To evaluate the efficacy of JTT against intractable and recurrent infections in immature immune systems, we administered JTT to otitis-prone infants and investigated clinical changes before and during JTT administration. SUBJECTS AND METHODS: Twenty-four otitis-prone infants were administered JTT at 0.10-0.14 g/kg/day twice a day for 3 months. We compared clinical course, such as frequency of acute otitis media (AOM), duration of fever and antibiotics administration, and hospital visits for the periods before and during JTT administration. RESULTS: Medication compliance rate was 87.5%, and administration of JTT led to remission in 95.2% patients. No apparent side effects were observed. The frequency of AOM decreased significantly (Wilcoxon signed rank test, p=0.000) with JTT. The duration of fever (p=0.000) and administration of antibiotics (p=0.001), as well as the number of hospital visits (p=0.001) and emergent hospital visits (p=0.000) showed significant decreases after JTT administration. After the end of the JTT period, 14 of 21 (66.7%) patients started to take it again, as they experienced purulent otitis media and/or other infections after discontinuation. The frequency of AOM increased significantly after stopping JTT (p=0.004) and decreased again with JTT resumption (p=0.005). |
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Authors:
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Yumiko Maruyama; Shigeru Hoshida; Mitsuru Furukawa; Makoto Ito |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta oto-laryngologica Volume: 129 ISSN: 1651-2251 ISO Abbreviation: Acta Otolaryngol. Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2008-12-19 Completed Date: 2009-03-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370354 Medline TA: Acta Otolaryngol Country: Norway |
Other Details:
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Languages: eng Pagination: 14-8 Citation Subset: IM |
Affiliation:
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Department of Otorhinolaryngology, Kurobe City Hospital, 1108-1 Mikkaichi, Kurobe, Toyama, Japan. maruyama@med.kurobe.toyama.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Child, Preschool Dose-Response Relationship, Drug Drug Administration Schedule Drugs, Chinese Herbal / administration & dosage*, adverse effects Emergency Service, Hospital / utilization Female Hospitalization / statistics & numerical data Humans Infant Japan Male Otitis Media, Suppurative / prevention & control* Phytotherapy* Recurrence / prevention & control Referral and Consultation / utilization Utilization Review / statistics & numerical data |
| Chemical | |
Reg. No./Substance:
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0/Drugs, Chinese Herbal; 0/juzentaihoto |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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