Document Detail

Effects of Japanese herbal medicine, Juzen-taiho-to, in otitis-prone children--a preliminary study.
MedLine Citation:
PMID:  18608005     Owner:  NLM     Status:  MEDLINE    
CONCLUSION: Juzen-taiho-to (JTT, TJ-48), a Japanese herbal medicine that improves immune function, was found to be effective in otitis-prone in children. OBJECTIVE: To evaluate the efficacy of JTT against intractable and recurrent infections in immature immune systems, we administered JTT to otitis-prone infants and investigated clinical changes before and during JTT administration. SUBJECTS AND METHODS: Twenty-four otitis-prone infants were administered JTT at 0.10-0.14 g/kg/day twice a day for 3 months. We compared clinical course, such as frequency of acute otitis media (AOM), duration of fever and antibiotics administration, and hospital visits for the periods before and during JTT administration. RESULTS: Medication compliance rate was 87.5%, and administration of JTT led to remission in 95.2% patients. No apparent side effects were observed. The frequency of AOM decreased significantly (Wilcoxon signed rank test, p=0.000) with JTT. The duration of fever (p=0.000) and administration of antibiotics (p=0.001), as well as the number of hospital visits (p=0.001) and emergent hospital visits (p=0.000) showed significant decreases after JTT administration. After the end of the JTT period, 14 of 21 (66.7%) patients started to take it again, as they experienced purulent otitis media and/or other infections after discontinuation. The frequency of AOM increased significantly after stopping JTT (p=0.004) and decreased again with JTT resumption (p=0.005).
Yumiko Maruyama; Shigeru Hoshida; Mitsuru Furukawa; Makoto Ito
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta oto-laryngologica     Volume:  129     ISSN:  1651-2251     ISO Abbreviation:  Acta Otolaryngol.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-19     Completed Date:  2009-03-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370354     Medline TA:  Acta Otolaryngol     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  14-8     Citation Subset:  IM    
Department of Otorhinolaryngology, Kurobe City Hospital, 1108-1 Mikkaichi, Kurobe, Toyama, Japan.
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MeSH Terms
Acute Disease
Child, Preschool
Dose-Response Relationship, Drug
Drug Administration Schedule
Drugs, Chinese Herbal / administration & dosage*,  adverse effects
Emergency Service, Hospital / utilization
Hospitalization / statistics & numerical data
Otitis Media, Suppurative / prevention & control*
Recurrence / prevention & control
Referral and Consultation / utilization
Utilization Review / statistics & numerical data
Reg. No./Substance:
0/Drugs, Chinese Herbal; 0/juzentaihoto

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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