| Effects of JL13, a pyridobenzoxazepine with potential atypical antipsychotic activity, in animal models for schizophrenia. | |
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MedLine Citation:
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PMID: 11408566 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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JL13 [5-(4-methylpiperazin-1-yl)-8-chloro-pyrido[2,3-b][1,5] benzoxazepine fumarate] is a substance with a close structural resemblance to clozapine. However, it is less sensitive to oxidation and may therefore have less hematological side effects. In the present study, JL13 was compared with clozapine and haloperidol in several animal models for schizophrenia. The paw test represents a screening model for antipsychotic drugs that can discriminate between drugs with extrapyramidal side effects and drugs without. Haloperidol increased both forelimb retraction time and hindlimb retraction time (HRT), whereas both clozapine and JL13 increased only HRT. In the prepulse inhibition paradigm, all three drugs reversed the apomorphine- and the amphetamine-induced disruption of prepulse inhibition. However, whereas haloperidol was equally effective against both dopaminergic drugs, JL13 and clozapine were more effective against amphetamine. Finally, only JL13 was able to increase prepulse inhibition in normal rats, whereas only clozapine reduced basal startle amplitude. Taken together, these data suggest that JL13 may be an effective antipsychotic drug, with a profile similar to clozapine. |
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Authors:
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B A Ellenbroek; J F Liégeois; J Bruhwyler; A R Cools |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of pharmacology and experimental therapeutics Volume: 298 ISSN: 0022-3565 ISO Abbreviation: J. Pharmacol. Exp. Ther. Publication Date: 2001 Jul |
Date Detail:
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Created Date: 2001-06-15 Completed Date: 2001-07-19 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0376362 Medline TA: J Pharmacol Exp Ther Country: United States |
Other Details:
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Languages: eng Pagination: 386-91 Citation Subset: IM |
Affiliation:
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Department of Psychoneuropharmacology, University of Nijmegen, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amphetamine Animals Antipsychotic Agents / pharmacology*, therapeutic use Benzodiazepinones / chemistry Central Nervous System Stimulants Clozapine / analogs & derivatives, pharmacology*, therapeutic use Disease Models, Animal* Drug Evaluation, Preclinical Haloperidol / pharmacology, therapeutic use Locomotion / drug effects*, physiology Male Pyridines / chemistry Rats Rats, Wistar Schizophrenia* / drug therapy Startle Reaction / drug effects*, physiology |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents; 0/Benzodiazepinones; 0/Central Nervous System Stimulants; 0/Pyridines; 10321-12-7/propizepine; 174762-89-1/JL 13 compound; 300-62-9/Amphetamine; 52-86-8/Haloperidol; 5786-21-0/Clozapine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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