Document Detail


Effects of Ivabradine on 6-Minute Walk Test and Quality of Life in Patients With Previously Implanted CRT-D.
MedLine Citation:
PMID:  23851959     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: We aimed to evaluate clinical effects of additional heart rate control by ivabradine on life quality score and 6-minute walking test in patients with previously implanted biventricular cardiac resynchronization therapy defibrillator (CRT-D) with ischemic heart failure under regular treatment.
METHODS: Fifteen men and 14 women with a median age of 63 years (range, 48-79 years) were studied. Twenty-one patients were in New York Heart Association class II (8 patients were in class III), CRT-D implanted previously, and with resting heart rates greater than 70 beats per minute with sinus rhythm despite conventional medication. Patients were given 2.5- to 7.5-mg ivabradine orally twice a day, and drug dosage was titrated to decrease the patients' average heart rate to 70 beats per minute. Before and 3 months after ivabradine treatment, all patients underwent extensive clinical, echocardiographic, and laboratory evaluation.
RESULTS: Ivabradine treatment produced dose-dependent reductions in heart rate at rest and at peak exercise (91.9 ± 6.3 to 71.7 ± 4.8 and 114.4 ± 7.6 to 96.8 ± 4.8; P = 0.001 and P = 0.001, respectively). There were also significant improvements in life quality score (52.4 ± 9.5 to 37.9±7.8; P = 0.001) and 6-minute walking distance (278.7 ± 85.8 to 373.3 ± 94.0; P = 0.001) of patients. All patients with New York Heart Association class III became class II after 3 months of ivabradine treatment.
CONCLUSION: Heart rate reduction in a short-term period by ivabradine produced significant improvements in exercise capacity and life quality in patients with CRT-D and conventional therapy.
Authors:
Ismail Ates; Asuman H Yavuz; Mehmet Doğru; Ahmet Genç; Seref Ulucan; Metin Sarkaya; Ramazan Cetinkaya; Ahmet Keser; Mahmut Akpek; Mehmet G Kaya
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-7-11
Journal Detail:
Title:  Journal of investigative medicine : the official publication of the American Federation for Clinical Research     Volume:  -     ISSN:  1708-8267     ISO Abbreviation:  J. Investig. Med.     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-7-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9501229     Medline TA:  J Investig Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
From the Departments of *Cardiology and †Nephrology and Transplantation, Medical Park Hospital, Antalya, Turkey; ‡Department of Cardiology, School of Medicine, Mevlana University, Konya, Turkey; §Department of Nephrology, Antalya Research and Education Hospital, Antalya, Turkey; and ∥Department of Cardiology, Erciyes University School of Medicine, Kayseri, Turkey.
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