| Effects of insulin on the vasculature. | |
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MedLine Citation:
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PMID: 20807190 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Revascularization procedures used for the treatment of cardiovascular disease can be associated with restenosis, although drug-coated stents have greatly reduced this complication. Both type 2 diabetes (T2DM) and metabolic syndrome (MetS) are associated with a high risk for atherosclerosis and restenosis. Insulin resistance, defined as the inability of insulin to exert its metabolic actions, characterizes both T2DM and MetS. Recent data suggest that insulin resistance is directly implicated in atherosclerosis/restenosis, because of the unresponsiveness to the vasculoprotective action of insulin, including its phosphoinositide 3-kinase (PI3K)-Akt-endothelial nitric oxide synthase mediated enhancement of endothelial function. However, insulin also has 'atherogenic' actions, including enhancement of vascular smooth muscle cell (VSMC) proliferation, which are mitogen-activated protein kinase-mediated. These 'atherogenic' actions are less affected by insulin resistance, which mainly involves the PI3K pathway. The role of insulin in the atherosclerotic disease process is still highly controversial, where some investigators view insulin as a growth factor with pro-atherogenic effects while some others believe insulin resistance to be pro-atherogenic rather than insulin itself. We attempt to produce a balanced review with a focus on the effect of insulin in vivo, in animal models of atherosclerosis and restenosis. |
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Authors:
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Danna M Breen; Adria Giacca |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current vascular pharmacology Volume: 9 ISSN: 1875-6212 ISO Abbreviation: Curr Vasc Pharmacol Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101157208 Medline TA: Curr Vasc Pharmacol Country: United Arab Emirates |
Other Details:
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Languages: eng Pagination: 321-32 Citation Subset: IM |
Affiliation:
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Department of Physiology, University of Toronto, Toronto M5S 1A8, Canada. adria.giacca@utoronto.ca. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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