Document Detail


Effects of Inhibitory Activity on Mycelial Growth of Candida albicans and Therapy for Murine Oral Candidiasis by the Combined Use of Terpinen-4-ol and a Middle-chain Fatty Acid, Capric Acid.
MedLine Citation:
PMID:  23292030     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The combined effect of terpinen-4-ol, the main component of tea tree oil, and capric acid against mycelial growth of Candida albicans and murine oral candidiasis was evaluated in vitro and in vivo. Mycelial growth of C. albicans was estimated by the Cristal violet method. Combination of these compounds revealed a potent synergistic inhibition of growth. Therapeutic efficacy of the combination was evaluated microbiologically in murine oral candidiasis, and its application of the compounds clearly demonstrated therapeutic activity. Based on these results, the combined agent of terpinen-4-ol and capric acid was discussed as a possible candidate for oral candidiasis therapy.
Authors:
Kentaro Ninomiya; Kazumi Hayama; Sanae Ishijima; Miki Takahashi; Junichi Kurihara; Shigeru Abe
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan     Volume:  133     ISSN:  1347-5231     ISO Abbreviation:  Yakugaku Zasshi     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0413613     Medline TA:  Yakugaku Zasshi     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  133-40     Citation Subset:  IM    
Affiliation:
Teikyo University Institute of Medical Mycology, Teikyo University.
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