Document Detail


Effects of in utero antiretroviral exposure on longitudinal growth of HIV-exposed uninfected infants in Botswana.
MedLine Citation:
PMID:  21124227     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The impact of in utero exposure to highly active antiretroviral therapy (HAART) on longitudinal growth of HIV-uninfected infants is unknown.
METHODS: The Mashi and Mma Bana PMTCT intervention trials enrolled HIV-infected pregnant women at four sites in Botswana. Breast-fed (BF), HIV-uninfected infants born at 37 weeks or greater were included in this analysis. Weight-for-age (WAZ), length-for-age (LAZ), and weight-for-length (WLZ) z-scores were calculated using World Health Organization Child Growth Standards. Mean z-scores were compared between in utero antiretroviral exposure groups using Student t test, response profiles analysis, and general linear mixed effects modeling.
RESULTS: Growth of 619 HAART-exposed and 440 zidovudine-exposed, HIV-uninfected infants was evaluated. Mean birth weights were 3.01 kg for HAART and 3.15 kg for zidovudine-exposed infants (P < 0.001) with lower mean birth WAZ, length-for-age (LAZ), and weight-for-length (WLZ) among HAART-exposed infants (all P < 0.001). HAART-exposed infants had greater improvement in WAZ and weight-for-length (WLZ) from birth through 2 months (P = 0.03, P < 0.001, respectively). The WAZ did not differ between groups from 3 through 6 months (P = 0.26). Length-for-age (LAZ) remained lower in HAART-exposed infants but the incidence of wasting or stunting did not differ between exposure groups.
CONCLUSIONS: Lower weights in HAART-exposed uninfected infants at birth were rapidly corrected during the first 6 months of life.
Authors:
Kathleen M Powis; Laura Smeaton; Anthony Ogwu; Shahin Lockman; Scott Dryden-Peterson; Erik van Widenfelt; Jean Leidner; Joseph Makhema; Max Essex; Roger L Shapiro
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of acquired immune deficiency syndromes (1999)     Volume:  56     ISSN:  1944-7884     ISO Abbreviation:  J. Acquir. Immune Defic. Syndr.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-18     Completed Date:  2011-02-16     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  100892005     Medline TA:  J Acquir Immune Defic Syndr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  131-8     Citation Subset:  IM; X    
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00197587;  NCT00270296
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MeSH Terms
Descriptor/Qualifier:
Adult
Anthropometry / methods
Antiretroviral Therapy, Highly Active*
Body Size
Botswana
Child Development / drug effects*
Female
HIV Infections / drug therapy*
Humans
Infant
Infant, Newborn
Male
Pregnancy
Pregnancy Complications, Infectious / drug therapy*
Prenatal Exposure Delayed Effects*
Grant Support
ID/Acronym/Agency:
#2P30AI060354-06/AI/NIAID NIH HHS; R01 HD037793/HD/NICHD NIH HHS; R01 HD037793-01A1/HD/NICHD NIH HHS; R01 HD37793/HD/NICHD NIH HHS; R01HD37793/HD/NICHD NIH HHS; TW00004/TW/FIC NIH HHS; U01 AI066454-01A1/AI/NIAID NIH HHS; U01-AI066454/AI/NIAID NIH HHS; UO1 AI066454/AI/NIAID NIH HHS
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