Document Detail

Effects of Ibuprofen on orthotopic glioma model in rats.
MedLine Citation:
PMID:  23146847     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the effects of ibuprofen (Ibp) on the vessel proliferation and necrosis in a rat glioma model.
STUDY DESIGN: Experimental, randomized interventional trial.
PLACE AND DURATION OF STUDY: 1st Neurosurgery Clinic in Bakirkoy Mental Diseases Hospital, Bakirkoy, Istanbul, Turkey, in the year 2010.
METHODOLOGY: After stereotactic injection of C6/LacZ rat glioma cells into the Wistar rats brain, the rats were randomly assigned to two treatment groups (group 1, control; group 2, Ibp treatment). Rats were sacrificed 18 days after treatment, and number of intra-/peri-tumoural vessels, microendothelial proliferations, immunohistochemistry and necrotic area were evaluated.
RESULTS: Ibp treatment significantly decreased tumour tissue, intratumoral vessel number and total tumour area level. The level of Ki67 was significantly decreased in the tumour tissue of group 2. Additionally, the total necrotic area / total tumour volume (%) was significantly less in the tumour tissue of the ibuprofen-treated rats compared to the controls.
CONCLUSION: The data show that the Ibp produced an important reduction in glioma tumour cell proliferation in the rat model.
Yasar Dagêstan; Ismail Karaca; Erol Rustu Bozkurt; Ayhan Bilir
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of the College of Physicians and Surgeons--Pakistan : JCPSP     Volume:  22     ISSN:  1681-7168     ISO Abbreviation:  J Coll Physicians Surg Pak     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-13     Completed Date:  2013-03-19     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  9606447     Medline TA:  J Coll Physicians Surg Pak     Country:  Pakistan    
Other Details:
Languages:  eng     Pagination:  690-3     Citation Subset:  IM    
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MeSH Terms
Angiogenesis Inducing Agents
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage,  therapeutic use*
Brain Neoplasms / drug therapy*,  pathology
Cell Line, Tumor / drug effects*,  pathology
Glioma / drug therapy*,  pathology
Ibuprofen / administration & dosage,  therapeutic use*
Rats, Wistar
Treatment Outcome
Reg. No./Substance:
0/Angiogenesis Inducing Agents; 0/Anti-Inflammatory Agents, Non-Steroidal; WK2XYI10QM/Ibuprofen

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