| Effects of Iberogast on proximal gastric volume, antropyloroduodenal motility and gastric emptying in healthy men. | |
| | |
MedLine Citation:
|
PMID: 17378904 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: The herbal preparation Iberogast has been reported to improve upper abdominal symptoms in functional dyspepsia (FD) and to decrease fundic tone, increase antral contractility, and decrease afferent nerve sensitivity in experimental animals. The effects of Iberogast on the human gastrointestinal tract have not been evaluated. METHODS: We investigated the effects of oral control and Iberogast, each administered as a single dose (1.1 mL), in a double-blind randomized fashion, on proximal gastric volume (part A), antropyloroduodenal motility (part B), and gastric emptying and intragastric distribution of a solid/liquid meal (part C) for 120 minutes, in nine (part A), 12 (part B), and eight (part C) healthy men. RESULTS: Iberogast increased proximal gastric volume (max volume; control 104+/-12 mL, Iberogast 174+/-23 mL, P<0.05) (part A), increased the motility index of antral pressure waves in the first 60 minutes (P<0.05) without affecting pyloric or duodenal pressures (part B), and slightly increased the retention of liquid in the total stomach between 10 and 50 minutes (P<0.01), but had no effect on gastric emptying of solids or intragastric distribution (part C). CONCLUSIONS: Iberogast affects gastric motility in humans, probably in a region-dependent manner. The stimulation of gastric relaxation and antral motility may contribute to the reported therapeutic efficacy of Iberogast in FD. |
| | |
Authors:
|
Amelia N Pilichiewicz; Michael Horowitz; Antonietta Russo; Anne F Maddox; Karen L Jones; Michael Schemann; Gerald Holtmann; Christine Feinle-Bisset |
Related Documents
:
|
8984014 - Influence of surgery on deglutitive upper oesophageal sphincter mechanics in zenker's d... 2762764 - Failed ileoanal anastomosis: correlations between clinical function and anal canal neur... 12098054 - Pylorus-preserving gastrectomy: effect on resistance through the sphincter of oddi comp... 3219524 - Sensory discrimination and dynamic activity in the anorectum: evidence using a new ambu... 475164 - Attenuation of prazosin effect on cardiac output in chronic heart failure. 21941684 - Nondipping in parkinson's disease. |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2007-03-22 |
Journal Detail:
|
Title: The American journal of gastroenterology Volume: 102 ISSN: 0002-9270 ISO Abbreviation: Am. J. Gastroenterol. Publication Date: 2007 Jun |
Date Detail:
|
Created Date: 2007-05-28 Completed Date: 2007-07-13 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0421030 Medline TA: Am J Gastroenterol Country: United States |
Other Details:
|
Languages: eng Pagination: 1276-83 Citation Subset: IM |
Affiliation:
|
University of Adelaide Discipline of Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Double-Blind Method Gastric Emptying / drug effects* Gastrointestinal Motility / drug effects* Humans Male Organ Size / drug effects Plant Extracts / administration & dosage, pharmacology* Stomach / drug effects*, physiology |
| Chemical | |
Reg. No./Substance:
|
0/Plant Extracts; 0/iberogast |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The role of nonenhanced magnetic resonance imaging in the early assessment of acute pancreatitis.
Next Document: Endoscopic drainage of pyogenic liver abscesses with suspected biliary origin.