| Effects of ICI 118.551, a selective beta-2 adrenergic blocking agent on the guinea pig cardiac excitability and ventricular fibrillation threshold. | |
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MedLine Citation:
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PMID: 11032054 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In isolated guinea pig perfused hearts ICI 118.551, a selective beta 2 adrenoceptor antagonist, induced transient ventricular extrasystoles. Following the termination of the perfusion, a very significant increase of both the ventricular fibrillation threshold and the refractory periods were measured. In guanethidine pretreated hearts, ICI 118.551 failed to induce premature beats. At the same time the fibrillation threshold and refractory periods exhibited a very significant decrease. The perfusion of equimolecular concentration of metoprolol, a beta-1-adrenoceptor antagonist, and (+) propranolol, a quinidine-like compound, induced, in most experimental settings, similar results as ICI 118.551. Thus, besides its beta-2-adrenoceptor antagonist properties, ICI 118.551 presented other pharmacological actions. |
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Authors:
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B Cuparencu; C Tomus; M Gozariu; A Cuprian |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Acta physiologica Hungarica Volume: 87 ISSN: 0231-424X ISO Abbreviation: Acta Physiol Hung Publication Date: 2000 |
Date Detail:
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Created Date: 2001-02-15 Completed Date: 2001-02-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8309201 Medline TA: Acta Physiol Hung Country: HUNGARY |
Other Details:
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Languages: eng Pagination: 113-26 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, University of Oradea, Romania. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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pharmacology* Animals Cardiac Pacing, Artificial Female Guanethidine / pharmacology Guinea Pigs Heart Conduction System / drug effects, physiology Male Perfusion Propanolamines / pharmacology* Sodium Glutamate / toxicity Ventricular Fibrillation / chemically induced, physiopathology, prevention & control* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Propanolamines; 142-47-2/Sodium Glutamate; 55-65-2/Guanethidine; 72795-19-8/ICI 118551 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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