Document Detail

Effects of ICI 118.551, a selective beta-2 adrenergic blocking agent on the guinea pig cardiac excitability and ventricular fibrillation threshold.
MedLine Citation:
PMID:  11032054     Owner:  NLM     Status:  MEDLINE    
In isolated guinea pig perfused hearts ICI 118.551, a selective beta 2 adrenoceptor antagonist, induced transient ventricular extrasystoles. Following the termination of the perfusion, a very significant increase of both the ventricular fibrillation threshold and the refractory periods were measured. In guanethidine pretreated hearts, ICI 118.551 failed to induce premature beats. At the same time the fibrillation threshold and refractory periods exhibited a very significant decrease. The perfusion of equimolecular concentration of metoprolol, a beta-1-adrenoceptor antagonist, and (+) propranolol, a quinidine-like compound, induced, in most experimental settings, similar results as ICI 118.551. Thus, besides its beta-2-adrenoceptor antagonist properties, ICI 118.551 presented other pharmacological actions.
B Cuparencu; C Tomus; M Gozariu; A Cuprian
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Acta physiologica Hungarica     Volume:  87     ISSN:  0231-424X     ISO Abbreviation:  Acta Physiol Hung     Publication Date:  2000  
Date Detail:
Created Date:  2001-02-15     Completed Date:  2001-02-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8309201     Medline TA:  Acta Physiol Hung     Country:  HUNGARY    
Other Details:
Languages:  eng     Pagination:  113-26     Citation Subset:  IM    
Department of Pharmacology, University of Oradea, Romania.
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MeSH Terms
Adrenergic beta-Antagonists / pharmacology*
Cardiac Pacing, Artificial
Guanethidine / pharmacology
Guinea Pigs
Heart Conduction System / drug effects,  physiology
Propanolamines / pharmacology*
Sodium Glutamate / toxicity
Ventricular Fibrillation / chemically induced,  physiopathology,  prevention & control*
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Propanolamines; 142-47-2/Sodium Glutamate; 55-65-2/Guanethidine; 72795-19-8/ICI 118551

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