Document Detail


Effects of hemodialysis therapy on sit-to-walk characteristics in end stage renal disease patients.
MedLine Citation:
PMID:  23212801     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Patients with end stage renal diseases (ESRD) undergoing hemodialysis (HD) have high morbidity and mortality due to multiple causes; one of which is dramatically higher fall rates than the general population. In spite of the multiple efforts aiming to decrease the high mortality and improve quality of life in ESRD patients, limited success has been achieved. If adequate interventions for fall prevention are to be achieved, the functional and mobility mechanisms consistent with falls in this population must be understood. Human movements such as sit-to-walk (STW) tasks are clinically significant, and analysis of these movements provides a meaningful evaluation of postural and locomotor performance in elderly patients with functional limitations indicative of fall risks. In order to assess the effects of HD therapy on fall risks, 22 sessions of both pre- and post-HD measurements were obtained in six ESRD patients utilizing customized inertial measurement units (IMU). IMU signals were denoised using ensemble empirical mode decomposition and Savistky-Golay filtering methods to detect relevant events for identification of STW phases. The results indicated that patients were slower to get out of the chair (as measured by trunk flexion angular accelerations, time to peak trunk flexion, and overall STW completion time) following the dialysis therapy session. STW is a frequent movement in activities of daily living, and HD therapy may influence the postural and locomotor control of these movements. The analysis of STW movement may assist in not only assessing a patient's physical status, but in identifying HD-related fall risk as well. This preliminary study presents a non-invasive method of kinematic measurement for early detection of increased fall risk in ESRD patients using portable inertial sensors for out-patient monitoring. This can be helpful in understanding the pathogenesis better, and improve awareness in health care providers in targeting interventions to identify individuals at risk for fall.
Authors:
Rahul Soangra; Thurmon E Lockhart; John Lach; Emaad M Abdel-Rahman
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.     Date:  2012-12-05
Journal Detail:
Title:  Annals of biomedical engineering     Volume:  41     ISSN:  1573-9686     ISO Abbreviation:  Ann Biomed Eng     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-22     Completed Date:  2013-09-25     Revised Date:  2014-04-02    
Medline Journal Info:
Nlm Unique ID:  0361512     Medline TA:  Ann Biomed Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  795-805     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Accidental Falls / prevention & control*
Biomechanical Phenomena
Biomedical Engineering
Female
Gait / physiology
Humans
Kidney Failure, Chronic / complications,  physiopathology*,  therapy*
Male
Middle Aged
Monitoring, Physiologic
Posture / physiology
Renal Dialysis / adverse effects*
Walking / physiology
Grant Support
ID/Acronym/Agency:
L30 AG022963/AG/NIA NIH HHS; L30-AG022963-04/AG/NIA NIH HHS; R01-OH009222/OH/NIOSH CDC HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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