Document Detail

Effects of Helicobacter pylori on histamine and carbachol stimulated acid secretion by human parietal cells.
MedLine Citation:
PMID:  8020799     Owner:  NLM     Status:  MEDLINE    
Helicobacter pylori (H pylori) infection is associated with hypo, normal, and hypersecretory disorders of the gastric mucosa. Pathophysiological pathways by which H pylori interacts with acid secretion are still unclear. The effects of H pylori on (14C) aminopyrine uptake by human parietal cells were examined as an indirect assay for acid secretion. Isolated oxyntic glands were stimulated with submaximal concentrations of histamine or carbachol and incubated with sonicates of different H pylori strains. Omeprazole and sonicates of Campylobacter jejuni served as positive and negative controls, respectively. Two of four H pylori strains reduced hydrochloric acid sequestration within the parietal cells significantly and in a dose dependent manner in up to 80%. Interaction with acid secretion may therefore constitute a factor contributing to a distinct pathogenicity of H pylori strains.
H Jablonowski; K J Hengels; N Kraemer; G Geis; W Opferkuch; G Strohmeyer
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Gut     Volume:  35     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-08-03     Completed Date:  1994-08-03     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  755-7     Citation Subset:  AIM; IM    
Department of Gastroenterology, Heinrich-Heine-University, Düsseldorf, Germany.
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MeSH Terms
Aminopyrine / metabolism
Carbachol / pharmacology
Dose-Response Relationship, Drug
Gastric Acid / secretion*
Helicobacter Infections / physiopathology*
Helicobacter pylori / physiology*
Histamine / pharmacology
Omeprazole / pharmacology
Parietal Cells, Gastric / metabolism
Stimulation, Chemical
Reg. No./Substance:
51-45-6/Histamine; 51-83-2/Carbachol; 58-15-1/Aminopyrine; 73590-58-6/Omeprazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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