Document Detail

Effects of Helichrysum ceres extracts on renal function and blood pressure in the rat.
MedLine Citation:
PMID:  12617328     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the effects of Helicrysum ceres root and leaf extracts on mean arterial blood pressure and renal fluid and electrolyte handling in anesthetized male Sprague-Dawley rats. DESIGN: Cross sectional study. SETTING: Departments of Physiology and Pharmacy, University of Zimbabwe. SUBJECTS: Eight separate groups comprising of control and treated Male Sprague-Dawley rats (n =6 in each group) were anesthetized and placed on a continuous jugular infusion of 0.077 M NaCl at 150 microL min(-1). The left carotid artery was cannulated with polythene tubing and then connected to a pressure transducer for blood pressure measurements. After 3 h equilibration period, consecutive 20 min urine collections and blood pressure measurements were made over the subsequent 4 h of 1 h 20 min control, 1 h treatment and I h 40 min post-equilibration periods for measurements of urine flow and Na+ and K+ excretion rates. Helichrysum ceres leaf extracts at 0.3, 0.6 and 1.2 microg min(-1) roots 0.3, 3 and 6 microg min(-1) were added to the infusate during the treatment period. To establish whether the extracts had activities comparable to drugs already in use, a separate group of animals was administered furosemide (0.12 microg min(-1)) during the treatment period. MAIN OUTCOME MEASURES: Hypotension, Natriuresis and Diuresis. RESULTS: Infusion of graded doses of aqueous leaf extracts of Helicrysum ceres provoked an increase in urine flow rates but did not achieve statistical significance. However, the extracts produced dose dependent decrease in potassium excretion as well as increases in urinary Na+ outputs and diuresis. Administration of the various doses of aqueous root extracts of Helicrysum ceres significantly increased urine flow rate and urinary Na+ excretion in all groups. The intravenous (i.v.) administration of the aqueous root or leaf extracts of Helichrysum ceres significantly depressed mean arterial blood pressure (MAP). The diuretic and natriuretic effects of plant extracts were not significantly different to that of furosemide. CONCLUSION: The results suggest that oral administration to rats of aqueous crude Helicrysum ceres root or leaves extracts induce hypotension and natriuresis.
C T Musabayane; O Munjeri; N D Mdege
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article    
Journal Detail:
Title:  Renal failure     Volume:  25     ISSN:  0886-022X     ISO Abbreviation:  Ren Fail     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2003-03-05     Completed Date:  2003-06-12     Revised Date:  2008-05-21    
Medline Journal Info:
Nlm Unique ID:  8701128     Medline TA:  Ren Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5-14     Citation Subset:  IM    
Department of Pharmacy, University of Zimbabwe, Mount Pleasant, Harare.
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MeSH Terms
Blood Pressure / drug effects*,  physiology*
Diuresis / drug effects,  physiology
Diuretics / administration & dosage
Dose-Response Relationship, Drug
Furosemide / administration & dosage
Infusions, Intravenous
Kidney / drug effects*,  physiology*
Models, Animal
Natriuresis / drug effects,  physiology
Plant Extracts / administration & dosage,  therapeutic use*
Plant Preparations / administration & dosage,  therapeutic use
Potassium / metabolism
Rats, Sprague-Dawley
Time Factors
Water-Electrolyte Balance / drug effects,  physiology
Reg. No./Substance:
0/Diuretics; 0/Plant Extracts; 0/Plant Preparations; 54-31-9/Furosemide; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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