Document Detail

Effects of the HeartMate II left ventricular assist device as observed by serial echocardiography.
MedLine Citation:
PMID:  23311405     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The HeartMate II is the most frequently used left ventricular assist device (LVAD) in patients with end-stage heart failure. There is a paucity of data regarding its longitudinal cardiac effects, particularly that on diastole.
METHODS: This retrospective study was an evaluation of echocardiograms preoperatively and at 3, 6, and 12 months postoperatively in patients with a HeartMate II. Measurements included left ventricle (LV) dimensions, ejection fraction (EF), right ventricle (RV) size and function, parameters of diastolic function, and an analysis of mitral regurgitation (MR), tricuspid regurgitation (TR), aortic insufficiency (AI), and aortic valve thickening.
RESULTS: Forty-seven patients were evaluated. LV dimensions decreased but EF, RV size, and RV function were unchanged. Right ventricular systolic pressure (RVSP) and diastolic parameters including mitral inflow E/A, deceleration time (DT), pulmonary vein inflow, left atrial size, and overall diastolic grade improved. LV relaxation measured by tissue Doppler (e') was unchanged and the E/e' ratio was also unchanged. Regarding valve function, MR decreased, TR was unchanged, and the aortic valve became increasingly thickened with increased AI severity.
CONCLUSIONS: The HeartMate II unloads the LV as shown by decreased LV size, decreased MR, reduced RVSP, and improved patterns of mitral inflow. However, neither systolic function nor diastolic relaxation improves in this cohort. RV size and function also remain unchanged. The aortic valve shows increased thickening and AI likely from valve leaflet fusion. These results provide detailed functional and hemodynamic information regarding the longitudinal effects of the HeartMate II.
Carrie B Chapman; Salman Allana; Nancy K Sweitzer; Takushi Kohmoto; Margaret Murray; David Murray; Maryl Johnson; Peter S Rahko
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2013-01-11
Journal Detail:
Title:  Echocardiography (Mount Kisco, N.Y.)     Volume:  30     ISSN:  1540-8175     ISO Abbreviation:  Echocardiography     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-09     Completed Date:  2013-10-21     Revised Date:  2014-11-08    
Medline Journal Info:
Nlm Unique ID:  8511187     Medline TA:  Echocardiography     Country:  United States    
Other Details:
Languages:  eng     Pagination:  513-20     Citation Subset:  IM    
Copyright Information:
© 2013, Wiley Periodicals, Inc.
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MeSH Terms
Cohort Studies
Echocardiography, Doppler / methods*
Follow-Up Studies
Heart Failure / mortality,  physiopathology,  surgery*,  ultrasonography*
Heart Function Tests
Heart-Assist Devices*
Hemodynamics / physiology*
Middle Aged
Monitoring, Physiologic
Postoperative Care
Postoperative Complications / mortality,  physiopathology,  ultrasonography
Preoperative Care
Retrospective Studies
Risk Assessment
Stroke Volume
Survival Rate
Treatment Outcome
Ventricular Function, Left / physiology
Ventricular Function, Right / physiology
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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