Document Detail

Effects of Guilingji on brain monoamines and their metabolites in mice.
MedLine Citation:
PMID:  1962529     Owner:  NLM     Status:  MEDLINE    
Guillingji powder, a complex prescription of traditional Chinese medicines, has been pharmacologically shown to be a possible anti-aging agent, and also used for the treatment of male hypogonadism and female dysgenesis. Since the levels of numerous brain monoamines and their metabolites such as norepinephrine (NE), dopamine (DA), dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), serotonin (5-HT), and 5-hydroxyindole acetic acid (5-HIAA) have been correlated with aging, we examined the effects of Guilingji powder and its extract on such monoamines and metabolites in the cerebrum and the cerebellum of mice using HPLC-ECD. The results showed that dietary intake of Guilingji powder had the effect of increasing the NE level and the DOPAC/DA ratio, and decreasing the 5-HT level and 5-HT/NE ratio in the cerebrum. In the cerebellum, the powder did not produce any changes in the levels of the compounds investigated. The extract of Guilingji, on the other hand, not only increased the NE level and the DOPAC/DA ratio but also the 5-HIAA/5-HT ratio in the cerebrum. However, the extract did not decrease the 5-HT in the cerebrum, although it decreased the 5-HT/NE. Unlike the powder, the extract had an effect in the cerebellum, which increased the DOPAC/DA ratio. These results suggest that Guilingji may have the action of modulating the levels and the metabolism of monoamines.
J K Liu; H Kabuto; M Hiramatsu; A Mori
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta medica Okayama     Volume:  45     ISSN:  0386-300X     ISO Abbreviation:  Acta Med. Okayama     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1992-01-06     Completed Date:  1992-01-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417611     Medline TA:  Acta Med Okayama     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  217-22     Citation Subset:  IM    
Department of Neurochemistry, Okayama University Medical School, Japan.
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MeSH Terms
Biogenic Monoamines / metabolism*
Brain Chemistry / drug effects*
Chromatography, High Pressure Liquid
Drugs, Chinese Herbal / pharmacology*
Mice, Inbred Strains
Reg. No./Substance:
0/Biogenic Monoamines; 0/Drugs, Chinese Herbal

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