| Effects of growth hormone and nutritional therapy in boys with constitutional growth delay: a randomized controlled trial. | |
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MedLine Citation:
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PMID: 20961566 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To examine whether supplemental nutrition augments the anabolic actions of growth hormone (GH) in boys with constitutional delay of growth and maturation (CDGM). STUDY DESIGN: We conducted a randomized, controlled trial at an outpatient clinical research center. Subjects were 20 prepubertal boys (age, 9.3 ± 1.3 years) with CDGM (height standard deviation score, -2.0 ± 0.5; bone age delay, 1.8 ± 0.8 years; body mass index standard deviation score, -1.2 ± 1.0; peak stimulated GH, 15.7 ± 7.7 ng/mL), who were randomized (n = 10/group) to 6 months observation or daily nutritional supplementation, followed by additional daily GH therapy in all for another 12 months. t tests and repeated measures analyses of variance compared energy intake, total energy expenditure (TEE), growth, hormones, and nutrition markers. RESULTS: Energy intake was increased at 6 months within the nutrition group (P = .04), but not the observation group, and TEE was not statistically different within either group at 6 months. Addition of 6 months GH resulted in higher energy intake and TEE in the GH/nutrition group at 12 months (P < .01), but not in the GH group versus baseline. Height, weight, lean body mass, hormones, and nutrition markers increased comparably in both groups throughout 18 months. CONCLUSION: Boys with CDGM use energy at an accelerated rate, an imbalance not overcome with added nutrition. GH therapy increases growth comparably with or without added nutrition in these patients. |
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Authors:
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Joan C Han; Ligeia Damaso; Susan Welch; Prabhakaran Balagopal; Jobayer Hossain; Nelly Mauras |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't Date: 2010-10-18 |
Journal Detail:
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Title: The Journal of pediatrics Volume: 158 ISSN: 1097-6833 ISO Abbreviation: J. Pediatr. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-14 Completed Date: 2011-04-05 Revised Date: 2013-05-27 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: United States |
Other Details:
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Languages: eng Pagination: 427-32 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2011 Mosby, Inc. All rights reserved. |
Affiliation:
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Division of Endocrinology, Nemours Children's Clinic, Jacksonville, FL 32207, USA. |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00102258 |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Child Combined Modality Therapy Dietary Supplements* Energy Metabolism Growth Disorders / diet therapy*, drug therapy* Human Growth Hormone / administration & dosage* Humans Male |
| Grant Support | |
ID/Acronym/Agency:
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Z99 HD999999/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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12629-01-5/Human Growth Hormone |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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