Document Detail


Effects of growth hormone and nutritional therapy in boys with constitutional growth delay: a randomized controlled trial.
MedLine Citation:
PMID:  20961566     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To examine whether supplemental nutrition augments the anabolic actions of growth hormone (GH) in boys with constitutional delay of growth and maturation (CDGM).
STUDY DESIGN: We conducted a randomized, controlled trial at an outpatient clinical research center. Subjects were 20 prepubertal boys (age, 9.3 ± 1.3 years) with CDGM (height standard deviation score, -2.0 ± 0.5; bone age delay, 1.8 ± 0.8 years; body mass index standard deviation score, -1.2 ± 1.0; peak stimulated GH, 15.7 ± 7.7 ng/mL), who were randomized (n = 10/group) to 6 months observation or daily nutritional supplementation, followed by additional daily GH therapy in all for another 12 months. t tests and repeated measures analyses of variance compared energy intake, total energy expenditure (TEE), growth, hormones, and nutrition markers.
RESULTS: Energy intake was increased at 6 months within the nutrition group (P = .04), but not the observation group, and TEE was not statistically different within either group at 6 months. Addition of 6 months GH resulted in higher energy intake and TEE in the GH/nutrition group at 12 months (P < .01), but not in the GH group versus baseline. Height, weight, lean body mass, hormones, and nutrition markers increased comparably in both groups throughout 18 months.
CONCLUSION: Boys with CDGM use energy at an accelerated rate, an imbalance not overcome with added nutrition. GH therapy increases growth comparably with or without added nutrition in these patients.
Authors:
Joan C Han; Ligeia Damaso; Susan Welch; Prabhakaran Balagopal; Jobayer Hossain; Nelly Mauras
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't     Date:  2010-10-18
Journal Detail:
Title:  The Journal of pediatrics     Volume:  158     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-14     Completed Date:  2011-04-05     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  427-32     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2011 Mosby, Inc. All rights reserved.
Affiliation:
Division of Endocrinology, Nemours Children's Clinic, Jacksonville, FL 32207, USA.
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00102258
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MeSH Terms
Descriptor/Qualifier:
Child
Combined Modality Therapy
Dietary Supplements*
Energy Metabolism
Growth Disorders / diet therapy*,  drug therapy*
Human Growth Hormone / administration & dosage*
Humans
Male
Grant Support
ID/Acronym/Agency:
Z99 HD999999/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
12629-01-5/Human Growth Hormone
Comments/Corrections

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