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Effects of Growth Environments and Two Environmental Endocrine Disruptors on Children with Idiopathic Precocious Puberty.
MedLine Citation:
PMID:  22318748     Owner:  NLM     Status:  Publisher    
Objective: The incidence of Idiopathic precocious puberty (IPP) might have an increasing trend. But the causes and risk factors of IPP are unknown. The objective of our study is to evaluate the effects of growth environments and two environmental endocrine disruptors (EDCs), zearalenone (ZEA) and 1,1-dichloro-2,2,bisethylene (p,p'-DDE), on patients with IPP.Design: Case-control study.Methods: It consisted of seventy-eight IPP patients at diagnosis and one hundred control children matched for age and sex. A questionnaire was designed to collect data of growth environments, and serum ZEA and p,p'-DDE were tested in all subjects. We analyzed data of growth environments, two EDCs and biological interaction between growth environments and EDCs.Results In growth environments, smallness for gestational age (SGA), maternal physical disease during pregnancy, early maternal menarche, early puberty of same-degree relatives and father absence in 4-6 years old were risk factors for children with IPP (P<0.05). Serum ZEA concentration, ZEA and p,p'-DDE positive rates in IPP group were significantly higher than the control (P<0.05). There was biological interaction between growth environments and ZEA (RERI=34.562, AP =0.745, S =4.193).Conclusions Results suggest possible effects of growth environments and two EDCs on the development of IPP. In addition, growth environments and ZEA have biological interaction which might increase the risk of developing IPP.
Fang Deng; Fang-Biao Tao; De-Yun Liu; Yuan-Yuan Xu; Jia-Hu Hao; Ying Sun; Pu-Yu Su
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-8
Journal Detail:
Title:  European journal of endocrinology / European Federation of Endocrine Societies     Volume:  -     ISSN:  1479-683X     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423848     Medline TA:  Eur J Endocrinol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
F Deng, Pediatrics, First Affiliated Hospital, Anhui Medical University, Hefei, 230022, China.
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