| Effects of Glucosamine and Chondroitin Sulfate on Cartilage Metabolism in OA: Outlook on Other Nutrient Partners Especially Omega-3 Fatty Acids. | |
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MedLine Citation:
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PMID: 21826146 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Osteoarthritis (OA) is a degenerative joint disease that is characterized by increasing loss of cartilage, remodeling of the periarticular bone, and inflammation of the synovial membrane. Besides the common OA therapy with nonsteroidal anti-inflammatory drugs (NSAIDs), the treatment with chondroprotectives, such as glucosamine sulfate, chondroitin sulfate, hyaluronic acid, collagen hydrolysate, or nutrients, such as antioxidants and omega-3 fatty acids is a promising therapeutic approach. Numerous clinical studies have demonstrated that the targeted administration of selected micronutrients leads to a more effective reduction of OA symptoms, with less adverse events. Their chondroprotective action can be explained by a dual mechanism: (1) as basic components of cartilage and synovial fluid, they stimulate the anabolic process of the cartilage metabolism; (2) their anti-inflammatory action can delay many inflammation-induced catabolic processes in the cartilage. These two mechanisms are able to slow the progression of cartilage destruction and may help to regenerate the joint structure, leading to reduced pain and increased mobility of the affected joint. |
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Authors:
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Jörg Jerosch |
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Publication Detail:
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Type: Journal Article Date: 2011-08-02 |
Journal Detail:
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Title: International journal of rheumatology Volume: 2011 ISSN: 1687-9279 ISO Abbreviation: Int J Rheumatol Publication Date: 2011 |
Date Detail:
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Created Date: 2011-08-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101519204 Medline TA: Int J Rheumatol Country: United States |
Other Details:
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Languages: eng Pagination: 969012 Citation Subset: - |
Affiliation:
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Department of Orthopedics, Trauma Surgery and Sports Medicine, Johanna-Etienne Hospital, 41462 Neuss, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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