Document Detail


Effects of Ginkgo biloba extract on heart and liver mitochondrial functions: mechanism(s) of action.
MedLine Citation:
PMID:  20300812     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Though extracts of Ginkgo biloba leaves (GBE) have a wide pharmacological application, little is known about GBE effects on mitochondria. In this work, effects of ethanolic GBE on the respiration of isolated rat heart and liver mitochondria were investigated. We found that GBE stimulates the pyruvate + malate-dependent State 2 respiration of heart mitochondria and decreases mitochondrial membrane potential. Uncoupling effect of GBE was found to be due to its protonophoric action and is likely to be mediated by the ATP/ADP-translocator and uncoupling proteins. The effect of GBE was less in liver than in heart mitochondria. State 3 respiration of heart mitochondria was slightly stimulated at low and depressed at higher GBE concentrations. Inhibition of State 3 respiration of heart mitochondria was not relieved by uncoupler indicating that GBE may inhibit the respiratory chain complexes or the substrate transport. However, Complex IV of the respiratory chain was not inhibited by GBE. H(2)O(2) generation was attenuated by low concentration of GBE probably due to mild uncoupling. The data suggest that mild but not severe uncoupling activity of GBE may be important in providing pharmacological protection of cellular functions in pathological situations.
Authors:
Giedre Baliutyte; Rasa Baniene; Sonata Trumbeckaite; Vilmante Borutaite; Adolfas Toleikis
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-19
Journal Detail:
Title:  Journal of bioenergetics and biomembranes     Volume:  42     ISSN:  1573-6881     ISO Abbreviation:  J. Bioenerg. Biomembr.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-08     Completed Date:  2010-08-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7701859     Medline TA:  J Bioenerg Biomembr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  165-72     Citation Subset:  IM    
Affiliation:
Institute for Biomedical Research, Kaunas University of Medicine, Eiveniu str. 4, LT-50009, Kaunas, Lithuania.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Respiration / drug effects
Ethanol
Ginkgo biloba / chemistry*
Hydrogen Peroxide / metabolism
Membrane Potential, Mitochondrial / drug effects
Mitochondria, Heart / drug effects*,  metabolism
Mitochondria, Liver / drug effects*,  metabolism
Plant Extracts / pharmacology*
Plant Leaves / chemistry*
Rats
Uncoupling Agents / pharmacology
Chemical
Reg. No./Substance:
0/Plant Extracts; 0/Uncoupling Agents; 64-17-5/Ethanol; 7722-84-1/Hydrogen Peroxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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